| Item type |
文献 / Documents(1) |
| 公開日 |
2016-05-26 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-Ay mice. |
|
言語 |
en |
| 著者 |
保坂, 利男
ササガ, サヤカ
ヤマサカ, ユキコ
ニイ, ヨシタカ
エダザワ, カズヒロ
堤, 理恵
首藤, 恵泉
オカヒサ, ナオキ
イワタ, シンヤ
友竹, 浩之
酒井, 徹
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-Ay mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of β-oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
buckwheat |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
triglyceride |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fatty liver |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lypogenesis |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 61,
号 3-4,
p. 345-352,
発行日 2014-08
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
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収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
296181 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
LID201605265001.pdf (663 KB)
