WEKO3
アイテム
アクアポリン5自然発生遺伝子変異の水チャネル機能におよぼす影響
https://tokushima-u.repo.nii.ac.jp/records/2003047
https://tokushima-u.repo.nii.ac.jp/records/2003047f9177ce4-291e-44ea-bb2c-3907ef732e78
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201608242007.pdf (7.05 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2016-08-24 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | アクアポリン5自然発生遺伝子変異の水チャネル機能におよぼす影響 | |||||||||||
| タイトル | ||||||||||||
| タイトル | アクアポリン5 シゼン ハッセイ イデンシ ヘンイ ノ ミズ チャネル キノウ ニ オヨボス エイキョウ | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | Effects of a Naturally Occurring Mutation in Rat Aquaporin 5 on its Water Channel Functions | |||||||||||
| 著者 |
細井, 和雄
× 細井, 和雄
WEKO
169
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| 抄録 | ||||||||||||
| 内容記述 | The aquaporin (AQP) family in mammals is composed of 13 members (AQP0-12) of water channel proteins. One of them, AQP5, is expressed in the various exocrine glands such as the lachrymal, parotid, and submandibular gland, and also in lung. We found the presence of G>A point mutation at position 308 in the rat AQP5 mRNA as well as the genome DNA. This mutation resulted in replacement of Gly103 with Asp103 in the AQP5 protein molecule, and led to various phenotypic alterations in the salivary gland. The point mutation localized in the 3rd trans-membrane domain, which is remote site from the water pore. As expected, the water permeability of the mutant molecule was almost same as that of the wild type molecule, indicating that the mutation does not affect the water permeability. In the submandibular gland, membrane expression of the mutant molecule was extremely reduced; and the secretion of saliva in the mutant rat was reduced also as compared to the wild-type animals. By confocal immunohistochemistry, an increased association of AQP5 and lysosomal markers, Lamp2 and/or cathepsin D was observed in the cytoplasmic area of acinar cells of mutant rats, implying the accelerated metabolism of the mutant molecule by the lysosomal system. |
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| キーワード | ||||||||||||
| 主題 | アクアポリン | |||||||||||
| キーワード | ||||||||||||
| 主題 | 水チャネル | |||||||||||
| キーワード | ||||||||||||
| 主題 | 外分泌腺 | |||||||||||
| キーワード | ||||||||||||
| 主題 | 遺伝子変異 | |||||||||||
| 書誌情報 |
ja : 四国歯学会雑誌 巻 24, 号 2, p. 51-57, 発行日 2012-01-31 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 09146091 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN10050046 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 四国歯学会 | |||||||||||
| EID | ||||||||||||
| 識別子 | 242884 | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
