| Item type |
文献 / Documents(1) |
| 公開日 |
2017-11-16 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Implications of heat shock / stress proteins for medicine and disease |
|
言語 |
en |
| 著者 |
六反, 一仁
ヒラカワ, テツヤ
(手嶋)近藤, 茂忠
ナカノ, ヨウコ
ミヨシ, マミ
河合, 智子
コンダ, エミ
モリナガ, ヒロコ
二川, 健
岸, 恭一
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Heat shock/ stress proteins (HSPs) are crucial for maintenance of cellular homeostasis during normal cell growth and for survival during and after various cellular stresses. The HSP70 family functions as molecular chaperones and reduces stress-induced denaturation and aggregation of intracellular proteins. In addition to the chaperoning activities, HSP70 has been suggested to exert its protective action by protecting mitochondria and by interfering with the stress-induced apoptotic program. The biochemical and functional properties of HSPs observed in cultured cells may be relevant to organs and tissues in whole animals. The activation of the hypothalamic-pituitary-adrenal axis and the sympathetic nerve system elicits the stress response in selected peripheral tissues the HSP70 expression in the vasculature and stomach increases resistance against hemodynamic stress and stress-induced mucosal damage, respectively. Gastric mucosa pretreated with mild irritants acquires a tolerance against subsequent mucosal-damaging insults. This phenomenon is known as “adaptive cytoprotection”. Transient ischemia also induces ischemic tolerance in the brain and heart, which is called “ischemic preconditioning”. The heat shock response is believed to contribute to the acquisition of the tolerance. The therapeutic applications of chaperone inducers that induce HSPs without any toxic effect are also introduced. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
heat shock / stress proteins |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
physiologic stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
stress ulcer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ischemic tolerance |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chaperone inducers |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 44,
号 3-4,
p. 137-147,
発行日 1998
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
135027 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_44_3-4_137.pdf (298 KB)
