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Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin
https://tokushima-u.repo.nii.ac.jp/records/2003869
https://tokushima-u.repo.nii.ac.jp/records/20038696fc97fe5-7a03-4fae-b264-081640bd9d12
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jmi_50_1-2_1.pdf (205 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||
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| 公開日 | 2017-11-22 | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin | |||||||||||||
| 言語 | en | |||||||||||||
| 著者 |
Yao, Dengfu
× Yao, Dengfu
× 桒島, 正道
× 木戸, 博 |
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | The pathogenesis of influenza encephalopathy or encephalitis is poorly understood. This review summarizes our recent studies of the roles played by inflammatory cytokines, inducible nitric oxide synthase (iNOS), adhesion molecules and mini-plasmin in influenza encephalitis. After the intranasal infection of newborn mice with the non-neurotropic strain of influenza A virus (IAV) Aichi/2/68/H3N2, encephalitis and severe brain edema were observed within 3-5 days. IAV-RNA and abnormalities in the blood-brain barrier permeability were detected in association with an increase in them RNA expressions of endothelin-1, iNOS, and tumor necrosis factor-α. Furthermore, the accumulation in the brain capillaries of mini-plasmin, which proteolytically induces the viral envelope fusion activity and allows the virus to enter the cells, changes the brain from non-susceptible to susceptible to non-neurotropic IAV multiplication. The accumulation of mini-plasmin was markedly greater in newborn mice with an impaired mitochondrial fatty acid metabolism. These inflammatory mediators and the accumulation of mini-plasmin in the brain may play an important role in the onset and progression of IAV encephalitis. | |||||||||||||
| 言語 | en | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | influenza encephalitis | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | cytokines | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | nitric oxide synthase | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | mini-plasmin | |||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 50, 号 1-2, p. 1-8, 発行日 2003 |
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| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||
| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||
| EID | ||||||||||||||
| 識別子 | 154897 | |||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
