| Item type |
文献 / Documents(1) |
| 公開日 |
2018-01-23 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.2152/jmi.52.57 |
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言語 |
ja |
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|
関連名称 |
10.2152/jmi.52.57 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
No association of the Trp 64 Arg mutation of the β3-adrenergic receptor gene with obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension in Japanese patients with schizophrenia |
|
言語 |
en |
| 著者 |
ナガノ, タカマサ
マツダ, ユキヒコ
谷岡, 哲也
ヨシオカ, タカオキ
ヒロイ, タダシ
ヨシカワ, ケンイチ
オカベ, ケンイチロウ
大坂, 京子
ナガミネ, イサオ
タカサカ, ヨウイチロウ
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
This study was conducted to address the question of whether the β3-adrenergic receptor gene mutation (Trp 64 Arg) is associated with metabolic disease in Japanese patients with schizophrenia. Methods : In a cross-sectional study, 89 participants were grouped into three genotypes. The 64 Arg allelic frequency in patients with or without metabolic disease was analyzed. Anthropometrics variables and biochemical parameters were compared among the genotypes. Results : The 64 Arg allele, which had a frequency of 0.22, was not associated with obesity, type 2 diabetes mellitus, dyslipidemias, or hypertension. No significant differences among the genotypes were found in current age, age at diagnosis with schizophrenia, body mass index, waist-hip ratio, plasma glucose, plasma insulin, triglycerides, free fatty acids. Patients with the 64 Arg allele had greater 24-h excretion of norepinephrine than those lacking the variant (p=0.019). Conclusion : The 64Arg allelic mutation is not associated with obesity, type 2 diabetes mellitus, lipid metabolism dysfunction, or hypertension in Japanese patients with schizophrenia. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
schizophrenia |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
β 3-adrenergic receptor polymorphism |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
obesity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
metabolic disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Trp 64 Arg allele |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 52,
号 1-2,
p. 57-64,
発行日 2005-02
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
132590 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_52_1-2_57.pdf (74.6 KB)
