| Item type |
文献 / Documents(1) |
| 公開日 |
2018-01-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.52.85 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.52.85 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Elevation of macrophage-derived chemokine in eosinophilic pneumonia : a role of alveolar macrophages |
|
言語 |
en |
| 著者 |
マナベ, カズヨシ
西岡, 安彦
岸, 潤
イナヤマ, マミ
青野, 純典
ナカムラ, ヨウイチ
オオグシ, フミタカ
バンドウ, ヒロヤス
谷, 憲治
曽根, 三郎
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Macrophage-derived chemokine (MDC/CCL22) and thymus-and activation-regulated chemokine (TARC/CCL17) are ligands for CC chemokine receptor 4. Recently, TARC has been reported to play a role in the pathogenesis of idiopathic eosinophilic pneumonia (IEP). The purpose of this study was to evaluate the role of MDC in IEP and other interstitial lung diseases (ILDs). MDC and TARC in the bronchoalveolar lavage fluid (BALF) were measured by enzymelinked immunosorbent assay in patients with ILDs and healthy volunteers (HV). We also examined the expression of MDC mRNA in alveolar macrophages (AM) by real-time quantitative reverse transcriptase-polymerase chain reaction. Both MDC and TARC were detected only in BALF obtained from IEP patients. The concentration of MDC was higher than that of TARC in all cases. The level of MDC in IEP correlated with that of TARC. AM from IEP patients expressed a significantly higher amount of MDC than that from HV at the levels of protein and mRNA. MDC in BALF from IEP dramatically decreased when patients achieved remission. These findings suggest that MDC, in addition to TARC, might be involved in the pathogenesis of IEP, and AM play a role in the elevation of MDC in IEP. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bronchoalveolar lavage fluid |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
macrophage-derived chemokine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
thymus-and activation-regulated chemokine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
eosinophilic pneumonia |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alveolar macrophages |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
interstitial lung diseases |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 52,
号 1-2,
p. 85-92,
発行日 2005-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
136629 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_52_1-2_85.pdf (202 KB)
