| Item type |
文献 / Documents(1) |
| 公開日 |
2018-01-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.52.93 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.52.93 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases |
|
言語 |
en |
| 著者 |
キムラ, マコト
谷, 憲治
ミヤタ, ジュンヤ
サトウ, ケイコ
ハヤシ, アキヒト
オオツカ, シンサク
浦田, 知之
曽根, 三郎
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To determine the significance of proteases in interstitial lung diseases, we examined the activity of cathepsins, thrombin, and aminopeptidase in bronchoalveolar lavage (BAL) fluid from patients with these disorders. Significantly increased activities of cathepsin H and aminopeptidase were detected in BAL fluid from patients with idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), chronic eosinophilic pneumonia (CEP) and hypersensitivity pneumonitis (HP). Significantly higher activity of cathepsin B was found in BAL fluid from patients with CEP. The activity of thrombin was significantly higher in patients with IPF and CEP. In patients with IPF, there were significant correlations between neutrophil number and the activity of cathepsin B, cathepsin H or aminopeptidase. In patients with COP and HP, the activity of the proteases was significantly higher in patients with higher number of lymphocytes than in those with lower number of lymphocytes. The present study suggests that the activity of the proteases is a useful marker in activity of the interstitial lung diseases, and may have a role in the pathogenesis of these disorders. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
interstitial lung diseases |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cathepsin H |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cathepsin B |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cathepsin G |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
thrombin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
aminopeptidase |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 52,
号 1-2,
p. 93-100,
発行日 2005-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
136618 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_52_1-2_93.pdf (853 KB)
