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Structure models of G72, the product of a susceptibility gene to schizophrenia
https://tokushima-u.repo.nii.ac.jp/records/2004087
https://tokushima-u.repo.nii.ac.jp/records/20040876724a978-e232-4f8e-a576-adb625bcff2f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jb_161_2_223.pdf (7.64 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2017-11-22 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.1093/jb/mvw064 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| タイトル | ||||||||||||
| タイトル | Structure models of G72, the product of a susceptibility gene to schizophrenia | |||||||||||
| 著者 |
加藤, 有介
× 加藤, 有介× 福井, 清
WEKO
271
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| 抄録 | ||||||||||||
| 内容記述 | The G72 gene is one of the most susceptible genes to schizophrenia and is contained exclusively in the genomes of primates. The product of the G72 gene modulates the activity of D-amino acid oxidase (DAO) and is a small protein prone to aggregate, which hampers its structural studies. In addition, lack of a known structure of a homologue makes it difficult to use the homology modeling method for the prediction of the structure. Thus, we first developed a hybrid ab initio approach for small proteins prior to the prediction of the structure of G72. The approach uses three known ab initio algorithms. To evaluate the hybrid approach, we tested our prediction of the structure of the amino acid sequences whose structures were already solved and compared the predicted structures with the experimentally solved structures. Based on these comparisons, the average accuracy of our approach was calculated to be ∼5 Å. We then applied the approach to the sequence of G72 and successfully predicted the structures of the N- and C-terminal domains (ND and CD, respectively) of G72. The predicted structures of ND and CD were similar to membrane-bound proteins and adaptor proteins, respectively. | |||||||||||
| キーワード | ||||||||||||
| 主題 | G72 | |||||||||||
| キーワード | ||||||||||||
| 主題 | ab initio method | |||||||||||
| キーワード | ||||||||||||
| 主題 | structure prediction | |||||||||||
| キーワード | ||||||||||||
| 主題 | schizophrenia | |||||||||||
| キーワード | ||||||||||||
| 主題 | D-amino acid oxidase | |||||||||||
| 書誌情報 |
en : The Journal of Biochemistry 巻 161, 号 2, p. 223-230, 発行日 2016-11-03 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 17562651 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0021924X | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA12096002 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00694073 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Oxford University Press | |||||||||||
| 備考 | ||||||||||||
| 値 | This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Biochemistry following peer review. The version of record, The Journal of Biochemistry (2017) Vol.161 Issue.2 p.223-230 is available online at: https://doi.org/10.1093/jb/mvw064. | |||||||||||
| EID | ||||||||||||
| 識別子 | 322896 | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
