| Item type |
文献 / Documents(1) |
| 公開日 |
2018-05-22 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.2152/jmi.56.93 |
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関連名称 |
10.2152/jmi.56.93 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats |
| 著者 |
ツチガウチ, タケシ
高橋, 徹行
オオニシ, タカマサ
小川, 博久
坂東, 良美
上原, 久典
タキザワ, タモツ
カネダ, シンヤ
ナカイ, トキコ
塩田, 洋
泉, 啓介
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| 抄録 |
|
|
内容記述 |
The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson’s disease, is resistant to a variety of chemical carcinogenesis except liver and colon. In the present study, N-ethyl-N-nitrosourea (ENU)-induced transplacental carcinogenesis was examined in male and female LEC, Long-Evans Agouti (LEA), a sibling line of the LEC rat, and F344 rats (n=21). ENU was administered to pregnant rats as a single s.c. injection at a dose of 60 mg/kg body weight on the 17th day after conception. Cerebral/spinal gliomas and trigeminal/spinal nerve schwannomas developed in both LEA and F344 rats at 30 weeks of age, but no nervous system tumors developed in LEC rats, the difference being statistically significant. Lung adenomas also developed in LEA and F344 rats, but not in LEC rats. Semiquantitative RT-PCR demonstrated that metallothionein (MT)1a, MT2 and O6-methylguanine-DNA methyltransferase (MGMT) mRNA levels in the liver of LEC rats were higher than those in F344 and LEA rats. In addition, Western blot analysis showed that MT (MT1 plus MT2) in the liver of LEC rats was also higher than that in other strains. Present results suggest that high levels of MT and/or MGMT contribute to the resistance to nitrosamine-induced carcinogenesis in LEC rats. |
| キーワード |
|
|
主題 |
Long-Evans Cinnamon rat |
| キーワード |
|
|
主題 |
Long-Evans Agouti rat |
| キーワード |
|
|
主題 |
N-ethyl-N-nitrosourea |
| キーワード |
|
|
主題 |
trigeminal schwannoma |
| キーワード |
|
|
主題 |
metallothionein |
| キーワード |
|
|
主題 |
O6-methylduanine-DNA methyltransferase |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 56,
号 3-4,
p. 93-98,
発行日 2009-08
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
|
|
出版者 |
Faculty of Medicine Tokushima University |
| EID |
|
|
識別子 |
224162 |
| 言語 |
|
|
言語 |
eng |
jmi_56_3-4_93.pdf (620 KB)
