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The essential role of luminal BK channels in distal colonic K+ secretion
https://tokushima-u.repo.nii.ac.jp/records/2004544
https://tokushima-u.repo.nii.ac.jp/records/20045444226f922-b1f0-4c49-bc2c-97de1bb85543
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jmi_56_suppl_301.pdf (39.9 KB)
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| Item type | 文献 / Documents(1) | |||||||||
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| 公開日 | 2018-06-07 | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||||||
| 資源タイプ | other | |||||||||
| 出版社版DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.2152/jmi.56.301 | |||||||||
| 言語 | ja | |||||||||
| 関連名称 | 10.2152/jmi.56.301 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| タイトル | ||||||||||
| タイトル | The essential role of luminal BK channels in distal colonic K+ secretion | |||||||||
| 言語 | en | |||||||||
| 著者 |
Sörensen, Mads V
× Sörensen, Mads V
× Leipziger, Jens
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Distal colonic K+ excretion is determined by the balance of K+ absorption and K+ secretion of the enterocytes. K+ secretion occurs via active basolateral K+ uptake mostly via the NKCC1 co-transporter followed by K+ exit via a luminal K+ channel. The specific focus here is directed towards the luminal secretory K+ channel (1). Several recent observations highlight the pivotal role of the large conductance, Ca2+-activated KCa1.1 (BK, KCNMA) channel as the only functionally relevant luminal K+ efflux pathway in mouse distal colon (2, 3). This conclusion was based on defining results from BK knock-out mice. The following key observations were made : 1. BK channels mediate the resting distal colonic K+ secretion (2, 4), 2. They are acutely stimulated by activation of luminal nucleotide receptor and elevations of intracellular Ca2+ (2, 4, 5), 3. Colonic BK channels are up-regulated by increases of plasma aldosterone (3), 4. In addition, the cAMP-stimulated distal colonic K+ secretion is apparently mediated via BK channels, 5. Finally, aldosterone was found to up-regulate specifically the ZERO (e.g. cAMP activated) C-terminal splice variant of the BK channel. In summary, we suggest that the sole exit pathway for transcellular K+ secretion in mammalian distal colon is the BK channel, which is the target for short term intracellular Ca2+ and cAMP activation and long term aldosterone regulation. | |||||||||
| 言語 | en | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | K+ channel | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | ion secretion | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | colon | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | epithelium | |||||||||
| 書誌情報 |
en : The Journal of Medical Investigation 巻 56, 号 Supplement, p. 301-301, 発行日 2009-12 |
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| 収録物ID | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 13496867 | |||||||||
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| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 13431420 | |||||||||
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| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11166929 | |||||||||
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| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12022913 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Faculty of Medicine Tokushima University | |||||||||
| 言語 | en | |||||||||
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| 言語 | eng | |||||||||
