| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2018-05-14 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1507/endocrj.42.331 |
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関連名称 |
10.1507/endocrj.42.331 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Two Different Pituitary Adenomas in a Patient with Multiple Endocrine Neoplasia Type 1 Associated with Growth Hormone-Releasing Hormone-Producing Pancreatic Tumor : Clinical and Genetic Features |
| タイトル別表記 |
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その他のタイトル |
TWO PITUITARY ADENOMAS IN MEN 1 |
| 著者 |
シンタニ, ヤスミ
吉本, 勝彦
ホリエ, ヒデアキ
佐野, 壽昭
カネサキ, ヨシコ
ホソイ, エミコ
ヨコゴシ, ユタカ
板東, 浩
イワハナ, ヒロユキ
カンヌキ, セイジ
マツモト, ケイゾウ
板倉, 光夫
齋藤, 史郎
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| 抄録 |
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内容記述 |
The clinical and genetic features of a 43-year-old male patient with multiple endocrine neoplasia type 1 were reported. He developed hyperparathyroidism, a GHRH-producing pancreatic tumor, and acromegaly between 1980 and 1983. Because his pituitary gland increased in size even after resecting the GHRH-producing pancreatic tumor, transsphenoidal hypophysectomy was performed six years later. The pituitary contained two histologically-different adenomas composed of somatotroph cells and null cells. Genetic analyses revealed loss of heterozygosity on chromosome 11 in common in the pituitary adenomas, the pancreatic endocrine tumors, and a parathyroid hyperplasia. On the other hand, mutations of ras, p53, Gsα, and Gi2α genes were not found in these tumors. The loss of the tumor suppressor gene on chromosome 11q12-13 was involved in the formation of two pituitary adenomas, two pancreatic endocrine functioning tumors, and a parathyroid hyperplasia in this patient, but the tumorigenic factors in the specific endocrine organs remain to be studied. |
| キーワード |
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主題 |
MEN 1 |
| キーワード |
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主題 |
Pituitary adenoma |
| キーワード |
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主題 |
Ectopic GHRH-producing tumor |
| キーワード |
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主題 |
Loss of heterozygosity |
| キーワード |
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主題 |
Chromosome 11 |
| 書誌情報 |
en : Endocrine Journal
巻 42,
号 3,
p. 331-340,
発行日 1995
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13484540 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
09188959 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10901436 |
| 出版者 |
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出版者 |
The Japan Endocrine Society |
| EID |
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識別子 |
71416 |
| 言語 |
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言語 |
eng |
endocrj_42_3_331.pdf (7.47 MB)
