| Item type |
文献 / Documents(1) |
| 公開日 |
2018-06-13 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.52.245 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.52.245 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Approach to novel functional foods for stress control : 4. Regulation of serotonin transporter by food factors |
|
言語 |
en |
| 著者 |
伊藤, 美紀子
ハイトウ, サキコ
フルモト, マリ
河合, 慶親
寺尾, 純二
宮本, 賢一
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Serotonin transporters (SERTs) are pre-synaptic proteins specialized for the clearance of serotonin following vesicular release at central nervous system (CNS) and enteric nervous system synapses. SERTs are high affinity targets in vivo for antidepressants such as serotonin selective reuptake inhibitors (SSRIs). These include ‘medical’ psychopharmacological agents such as analgesics and antihistamines, a plant extract called St John’s Wort (Hypericum) . Osteoclasts are the primary cells responsible for bone resorption. They arise by the differentiation of osteoclast precursors of the monocyte/macrophage lineage. The expression of SERTs was increased in RANKL-induced osteoclast-like cells. Using RANKL stimulation of RAW264.7 cells as a model system for osteoclast differentiation, we studied the direct effects of food factor on serotonin uptake. The SSRIs (fluoxetine and fluvoxamine) inhibited markedly (～95%) in serotonin transport in differentiated osteoclast cells. The major components of St. John’s Wort, hyperforin and hypericine were significantly decreased in serotonin transport activity. Thus, a new in vitro model using RANKL-induced osteoclast-like cells may be useful to analyze the regulation of SERT by food factors and SSRIs. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
serotonin transporter |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
serotonin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
osteoclast |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SSRI |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
St John’s wort |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 52,
号 Supplement,
p. 245-248,
発行日 2005-11
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
|
|
出版者 |
Faculty of Medicine Tokushima University |
|
言語 |
en |
| EID |
|
|
識別子 |
133903 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_52_supple_245.pdf (557 KB)
