| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-03 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1080/09168451.2016.1268042 |
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関連名称 |
10.1080/09168451.2016.1268042 |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells |
| 著者 |
ヨシダ, イチロウ
イトウ, チヒロ
マツダ, シンヤ
辻, 明彦
ヤナカ, ノリユキ
湯浅, 恵造
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| 抄録 |
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内容記述 |
To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Therefore, we investigated the mechanism underlying the inhibitory effect of alisol B on melanogenesis. Alisol B suppressed mRNA induction of tyrosinase and its transcription factor, microphthalmia-associated transcription factor (MITF). Furthermore, alisol B reduced the phosphorylation of CREB and maintained the activation of ERK1/2. These results suggest that the reduction in melanin production by alisol B is due to the downregulation of MITF through the suppression of CREB and activation of ERK, and that alisol B may be useful as a new whitening agent. |
| キーワード |
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|
主題 |
melanogenesis |
| キーワード |
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|
主題 |
alisol B |
| キーワード |
|
|
主題 |
Kampo |
| キーワード |
|
|
主題 |
tyrosinase |
| キーワード |
|
|
主題 |
microphthalmia-associated transcription factor (MITF) |
| 書誌情報 |
en : Bioscience, Biotechnology, and Biochemistry
巻 81,
号 3,
p. 534-540,
発行日 2017-01-04
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
09168451 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13476947 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10824164 |
| 出版者 |
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出版者 |
Japan Society for Bioscience, Biotechnology, and Agrochemistry |
| 出版者 |
|
|
出版者 |
Taylor & Francis |
| 備考 |
|
|
値 |
This is an electronic version of an article published in Bioscience, Biotechnology, and Biochemistry 81, 3, 534-540, 2017. Bioscience, Biotechnology, and Biochemistry is available online at: www.tandfonline.com/10.1080/09168451.2016.1268042. |
| EID |
|
|
識別子 |
322768 |
| 言語 |
|
|
言語 |
eng |
bbb_81_3_534.pdf (521 KB)
