| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-20 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.cbi.2017.12.013 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.cbi.2017.12.013 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
N-(3-oxododecanoyl)-l-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes : Its relation with intracellular Zn2+ |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, causes a bell-shaped change in nonprotein thiol content in rat thymic lymphocytes : Its relation with oxidative stress and intracellular Zn2+ |
|
言語 |
en |
| 著者 |
ニシムラ ダンジョウバラ, ユミコ
| ja |
ニシムラ ダンジョウバラ, ユミコ
|
| ja-Kana |
ニシムラ ダンジョウバラ, ユミコ
|
| en |
Nishimura-Danjobara, Yumiko
|
Search repository
オヤマ, ケイスケ
金丸, 芳
タカハシ, ケイコ
横井川, 久己男
小山, 保夫
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Cellular actions of N-(3-oxododecanoyl)-L-homoserine-lactone (ODHL), a quorum sensing molecule of bacteria, were studied on rat thymocytes using a flow cytometer with appropriate fluorescent dyes to elucidate the effects of ODHL on host cells. A bell-shaped concentration-response relation was observed in the ODHL-induced changes in cellular glutathione content ([GSH]i). ODHL concentration-dependently increased intracellular Zn2+ levels ([Zn2+]i) and cellular O2- content ([O2-]i). The bell-shaped relation induced by ODHL can be explained as follows: a low concentration of ODHL is expected to induce moderate oxidative stress that intracellularly releases Zn2+ by converting thiols to disulfides. A slight elevation of [Zn2+]i may increase the [GSH]i. On the other hand, it is likely that a high concentration of ODHL causes severe oxidative stress that further causes both the decrease in [GSH]i and the increase in [Zn2+]i. Excessive increase in [Zn2+]i may augment oxidative stress that further decreases the [GSH]i. Other notable actions induced by ODHL included the elevation of [Zn2+]i by Zn2+ influx and the increase in [GSH]i under Zn2+-free conditions. Therefore, it is suggested that ODHL elicits diverse actions on host cells. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Quorum sensing molecule |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
N-(3-oxododecanoyl)-L-homoserine-lactone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lymphocytes |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Intracellular Zn2+ levels |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Oxidative stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glutathione |
| 書誌情報 |
en : Chemico-Biological Interactions
巻 280,
p. 28-32,
発行日 2017-12-06
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00092797 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0060252X |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11523855 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
335217 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
cbi_280_28.pdf (2.18 MB)
