| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-20 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.tiv.2018.05.011 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.tiv.2018.05.011 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Cellular adverse actions of dibromoacetonitrile, a by-product in water bacterial control, at sublethal levels in rat thymocytes |
|
言語 |
en |
| 著者 |
キシダ, タクミ
アキヨシ, ケンジ
Erdenedalai, Erdenebat
Enhetomuru, Anu
今井, 昭二
小山, 保夫
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The aim of this study was to investigate the effects of dibromoacetonitrile (DBAN), a by-product in water bacterial control, at sublethal concentrations on rat thymocytes, by using a cytometric technique with appropriate fluorescent dyes. By using this method, the possibility that DBAN induces cellular actions related to oxidative stress was assessed. DBAN reduced the content of cellular nonprotein thiols under Zn2+-free conditions. It elevated the intracellular level of Zn2+, being independent from external Zn2+. DBAN increased cell vulnerability to the cytotoxic action of hydrogen peroxide. These actions of DBAN were likely related to oxidative stress. DBAN is formed by the reaction of bromides and chlorinated oxidants during water disinfection. Hydrolysis of 2,2-dibromo-3-nitrilopropionamide, an antimicrobial used in hydraulic fracturing fluids for production of shale gas and oil, produces DBAN. Therefore, the concern regarding the levels of DBAN in industrial water systems is necessary to avoid the environmental risk to humans and wild mammals. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dibromoacetonitrile |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Water disinfection |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nonprotein thiol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Intracellular Zn2+ level |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lymphocytes |
| 書誌情報 |
en : Toxicology in Vitro
巻 51,
p. 145-149,
発行日 2018-05-23
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
08872333 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10678594 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11540107 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
339536 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
tiv_51_145.pdf (2.09 MB)
