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Integrated stress response of vertebrates is regulated by four eIF2α kinases
https://tokushima-u.repo.nii.ac.jp/records/2005522
https://tokushima-u.repo.nii.ac.jp/records/200552264348274-dd66-41b0-b8ab-083ba40bf18d
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srep_6_32886.pdf (3.39 MB)
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srep_6_32886_s1.pdf (491 KB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||||||||||||||||||||||||||
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| 公開日 | 2018-11-12 | |||||||||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/srep32886 | |||||||||||||||||||||||||||||||||||
| 関連名称 | 10.1038/srep32886 | |||||||||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||
| タイトル | Integrated stress response of vertebrates is regulated by four eIF2α kinases | |||||||||||||||||||||||||||||||||||
| 著者 |
タニウチ, シュウスケ
× タニウチ, シュウスケ
× 三宅, 雅人
WEKO
500
× ツガワ, カズエ
× 親泊, 美帆
WEKO
478
× 親泊, 政一
WEKO
305
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| 抄録 | ||||||||||||||||||||||||||||||||||||
| 内容記述 | The integrated stress response (ISR) is a cytoprotective pathway initiated upon phosphorylation of the eukaryotic translation initiation factor 2 (eIF2α) residue designated serine-51, which is critical for translational control in response to various stress conditions. Four eIF2α kinases, namely heme-regulated inhibitor (HRI), protein kinase R (PKR), PKR-like endoplasmic reticulum kinase, (PERK) and general control non-depressible 2 (GCN2), have been identified thus far, and they are known to be activated by heme depletion, viral infection, endoplasmic reticulum stress, and amino acid starvation, respectively. Because eIF2α is phosphorylated under various stress conditions, the existence of an additional eIF2α kinase has been suggested. To validate the existence of the unidentified eIF2α kinase, we constructed an eIF2α kinase quadruple knockout cells (4KO cells) in which the four known eIF2α kinase genes were deleted using the CRISPR/Cas9-mediated genome editing. Phosphorylation of eIF2α was completely abolished in the 4KO cells by various stress stimulations. Our data suggests that the four known eIF2α kinases are sufficient for ISR and that there are no additional eIF2α kinases in vertebrates. | |||||||||||||||||||||||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 6, p. 32886, 発行日 2016-09-16 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||||||||||||||||
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| 値 | Supplementary Information : srep_6_32886_s1.pdf | |||||||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||||||
| 権利情報 | © The Author(s) 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||||||||||||||||||||
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| 識別子 | 330607 | |||||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||||
