| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-12 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1038/ncomms12597 |
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言語 |
ja |
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|
関連名称 |
10.1038/ncomms12597 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling |
|
言語 |
en |
| 著者 |
Gamrekelashvili, Jaba
Giagnorio, Roberto
Jussofie, Jasmin
Soehnlein, Oliver
Duchene, Johan
Briseño, Carlos G.
Ramasamy, Saravana K.
Krishnasamy, Kashyap
Limbourg, Anne
Häger, Christine
Kapanadze, Tamar
石舟, 智恵子
Hinkel, Rabea
Radtke, Freddy
Strobl, Lothar J.
Zimber-Strobl, Ursula
Napp, L. Christian
Bauersachs, Johann
Haller, Hermann
安友, 康二
Kupatt, Christian
Murphy, Kenneth M.
Adams, Ralf H.
Weber, Christian
Limbourg, Florian P.
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A population of monocytes, known as Ly6Clo monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6Chi monocytes into Ly6Clo monocytes in vivo and in vitro, thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen in vivo, while culture on recombinant DLL1 induces monocyte conversion in vitro. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 7,
p. 12597,
発行日 2016-08-31
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20411723 |
| 収録物ID |
|
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
Supplementary Information : ncomms_7_12597_s1.pdf
Corrigendum : https://doi.org/10.1038/ncomms15486 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
|
|
識別子 |
320154 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ncomms_7_12597.pdf (3.78 MB)
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