| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-07 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1080/09513590.2017.1409709 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1080/09513590.2017.1409709 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Effects of testosterone injection |
|
言語 |
en |
| 著者 |
岩佐, 武
松崎, 利也
矢野, 清人
ヤナギハラ, リエ
Mayila, Yiliyasi
苛原, 稔
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The effects of androgens on gonadotropin-releasing hormone (GnRH) secretion in females have not been fully established. To clarify the direct effects of androgens on hypothalamic reproductive factors, we evaluated the effects of chronic testosterone administration on hypothalamic GnRH regulatory factors in ovariectomized (OVX) female rats. Both testosterone and estradiol reduced the serum luteinizing hormone levels of OVX female rats, indicating that, as has been found for estrogen, testosterone suppresses GnRH secretion via negative feedback. Similarly, the administration of testosterone or estradiol suppressed the hypothalamic mRNA levels of kisspeptin and neurokinin B, both of which are positive regulators of GnRH, whereas it did not affect the hypothalamic mRNA levels of the kisspeptin receptor or neurokinin 3 receptor. On the contrary, the administration of testosterone, but not estradiol, suppressed the hypothalamic mRNA expression of prodynorphin, which is a negative regulator of GnRH. The administration of testosterone did not alter the rats’ serum estradiol levels, indicating that testosterone’s effects on hypothalamic factors might be induced by its androgenic activity. These findings suggest that as well as estrogen, androgens have negative feedback effects on GnRH in females and that the underlying mechanisms responsible for these effects are similar, but do not completely correspond, to the mechanisms underlying the effects of estrogen on GnRH. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Testosterone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
kisspeptin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
RFRP |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
NKB |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dynorphin |
| 書誌情報 |
en : Gynecological Endocrinology
巻 34,
号 5,
p. 437-441,
発行日 2017-11-29
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09513590 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14730766 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10839977 |
| 出版者 |
|
|
出版者 |
Taylor & Francis |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
This is an Accepted Manuscript of an article published by Taylor & Francis in Gynecological Endocrinology on 29/11/2017, available online: http://www.tandfonline.com/10.1080/09513590.2017.1409709. |
| EID |
|
|
識別子 |
339193 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
gye_34_5_437.pdf (342 KB)
