| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2018-11-08 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1152/ajpregu.00521.2015 |
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関連名称 |
10.1152/ajpregu.00521.2015 |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice |
| タイトル別表記 |
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その他のタイトル |
8-PN promotes recovery from muscle atrophy via Akt pathway |
| 著者 |
向井, 理恵
ホリカワ, ヒトミ
Lin, Pei-Yi
ツクモ, ナオ
二川, 健
カワムラ, トモユキ
根本, 尚夫
寺尾, 純二
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| 抄録 |
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内容記述 |
8-Prenylnaringenin (8-PN) is a prenylflavonoid that originates from hop extracts and is thought to help prevent disuse muscle atrophy. We hypothesized that 8-PN affects muscle plasticity by promoting muscle recovery under disuse muscle atrophy. To test the promoting effect of 8-PN on muscle recovery, we administered an 8-PN mixed diet to mice that had been immobilized with a cast to one leg for 14 days. Intake of the 8-PN mixed diet accelerated recovery from muscle atrophy, and prevented reductions in Akt phosphorylation. Studies on cell cultures of mouse myotubes in vitro demonstrated that 8-PN activated the PI3K/Akt/P70S6K1 pathway at physiologic concentrations. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atrophy. |
| キーワード |
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主題 |
disuse muscle atrophy |
| キーワード |
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主題 |
8-prenylnaringenin |
| キーワード |
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主題 |
IGF1/PI3K/Akt pathway |
| キーワード |
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主題 |
phosphorylation |
| キーワード |
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主題 |
nutritional supplement |
| 書誌情報 |
en : American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
巻 311,
号 6,
p. R1022-R1031,
発行日 2016-12-01
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03636119 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15221490 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00521155 |
| 出版者 |
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出版者 |
The American Physiological Society |
| EID |
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識別子 |
330023 |
| 言語 |
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言語 |
eng |
ajpregu_311_6_R1022.pdf (736 KB)
