| Item type |
文献 / Documents(1) |
| 公開日 |
2018-11-12 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/ncomms12849 |
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言語 |
ja |
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関連名称 |
10.1038/ncomms12849 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation |
|
言語 |
en |
| 著者 |
イワタ, ヒロシ
Goettsch, Claudia
Sharma, Amitabh
Ricchiuto, Piero
Goh, Wilson Wen Bin
Halu, Arda
ヤマダ, イワオ
吉田, 秀夫
ハラ, タクヤ
Wei, Mei
イノウエ, ノリユキ
福田, 大受
Mojcher, Alexander
Mattson, Peter C.
Barabási, Albert-László
Boothby, Mark
アイカワ
Singh, Sasha A.
アイカワ, マサノリ
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that PARP9 and PARP14 regulate macrophage activation. In primary macrophages, PARP9 and PARP14 have opposing roles in macrophage activation. PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNγ) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells. PARP9 silencing suppresses pro-inflammatory genes and STAT1 phosphorylation in M(IFNγ) cells. PARP14 induces ADP-ribosylation of STAT1, which is suppressed by PARP9. Mutations at these ADP-ribosylation sites lead to increased phosphorylation. Network analysis links PARP9–PARP14 with human coronary artery disease. PARP14 deficiency in haematopoietic cells accelerates the development and inflammatory burden of acute and chronic arterial lesions in mice. These findings suggest that PARP9 and PARP14 cross-regulate macrophage activation. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 7,
p. 12849,
発行日 2016-10-31
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20411723 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
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出版者 |
Springer Nature |
|
言語 |
en |
| 備考 |
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言語 |
ja |
|
値 |
Supplementary Information : ncomms_7_12849_s1.pdf |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
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|
識別子 |
331871 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ncomms_7_12849.pdf (4.6 MB)
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