| Item type |
文献 / Documents(1) |
| 公開日 |
2019-06-18 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1007/s00223-019-00525-0 |
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|
関連名称 |
10.1007/s00223-019-00525-0 |
| 出版タイプ |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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|
タイトル |
Regulation of α-klotho Expression by Dietary Phosphate During Growth Periods |
| タイトル別表記 |
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その他のタイトル |
成長期における食餌性リンによるα-klotho発現制御 |
| 著者 |
多々納(福田), 詩織
山本, 浩範
ナカハシ, オトキ
ヨシカワ, リョウヘイ
ハヤシ, マユ
キシモト, マキ
伊美, 友紀子
(山中)奥村, 仙示
大西, 康太
増田, 真志
竹谷, 豊
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| 抄録 |
|
|
内容記述 |
Inorganic phosphate (Pi) is an essential nutrient for maintaining various biological functions, particularly during growth periods. Excess intake of dietary Pi increases the secretion of fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) to maintain plasma Pi levels. FGF23 is a potent phosphaturic factor that binds to the α-klotho/FGFR complex in the kidney to promote excretion of Pi into the urine. In addition, excess intake of dietary Pi decreases renal α-klotho expression. Down-regulation or lack of α-klotho induces a premature aging-like phenotype, resulting from hyperphosphatemia, and leading to conditions such as ectopic calcification and osteoporosis. However, it remains unclear what effects dietary Pi has on α-klotho expression at different life stages, especially during growth periods. To investigate this, we used C57BL/6J mice in two life stages during growing period. Weaned (3 weeks old) and periadolescent (7 weeks old) were randomly divided into seven experimental groups and fed with 0.02, 0.3, 0.6, 0.9, 1.2, 1.5, or 1.8% Pi diets for 7 days. As a result, elevated plasma Pi and FGF23 levels and decreased renal α-klotho expression were observed in weaned mice fed with a high Pi diet. In addition, a high Pi diet clearly induced renal calcification in the weaned mice. However, in the periadolescent group, renal calcification was not observed, even in the 1.8% Pi diet group. The present study indicates that a high Pi diet in weaned mice has much greater adverse effects on renal α-klotho expression and pathogenesis of renal calcification compared with periadolescent mice. |
| キーワード |
|
|
主題 |
Dietary phosphate |
| キーワード |
|
|
主題 |
Growth periods |
| キーワード |
|
|
主題 |
α-Klotho |
| キーワード |
|
|
主題 |
FGF23 |
| キーワード |
|
|
主題 |
Vitamin D metabolism |
| キーワード |
|
|
主題 |
Kidney |
| 書誌情報 |
en : Calcified Tissue International
巻 104,
号 6,
p. 667-678,
発行日 2019-01-23
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0171967X |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14320827 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00141085 |
| 出版者 |
|
|
出版者 |
Springer Nature |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Shiori Fukuda-Tatanoの学位論文として提出され，学位審査・授与の対象となっている。
This is a post-peer-review, pre-copyedit version of an article published in Calcified Tissue International.
The final authenticated version is available online at: https://doi.org/10.1007/s00223-019-00525-0
学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻） |
| 権利情報 |
|
|
権利情報 |
© 2019, Springer Nature |
| EID |
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|
識別子 |
351695 |
| 言語 |
|
|
言語 |
eng |
| 報告番号 |
|
|
学位授与番号 |
甲第3278号 |
| 学位記番号 |
|
|
値 |
甲栄第267号 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2019-03-22 |
| 学位名 |
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|
学位名 |
博士（栄養学） |
| 学位授与機関 |
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|
学位授与機関名 |
徳島大学 |
k3278_abstract_review.pdf (200 KB)
