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Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis
https://tokushima-u.repo.nii.ac.jp/records/2006578
https://tokushima-u.repo.nii.ac.jp/records/200657817ecca27-e0bd-4564-b4e0-beb095d6075a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
crr_14_1_62.pdf (3.38 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2019-08-09 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.2174/1573397113666171017113441 | |||||||||||||||||
| 関連名称 | 10.2174/1573397113666171017113441 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis | |||||||||||||||||
| タイトル別表記 | ||||||||||||||||||
| その他のタイトル | Potential Role of Rebamipide in Osteoclast Differentiation | |||||||||||||||||
| 著者 |
井澤, 俊
× 井澤, 俊× フタミ, イスラミ ラフマ
× 田中, 栄二
WEKO
323
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| 内容記述 | Background: Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease that involves changes in subchondral bone and progressive degradation of cartilage. Currently, rebamipide, a gastroprotective drug, is administered to protect gastric mucosa and accelerate ulcer healing. Objectives: Recent studies have shown that rebamipide also attenuates cartilage degeneration by suppressing oxidative damage and inducing homeostasis of the extracellular matrix of articular chondrocytes. Regarding the latter, reduced expression of cathepsin K, NFATc1, c-Src, and integrin β3, and increased expression of nuclear factor-kappa B, have been found to be mediated by the transcription factor, receptor activator of nuclear factor kappa-B ligand (RANKL). Methods: Treatment with rebamipide was also found to activate, mitogen-activated protein kinases such as p38, ERK, and JNK to reduce osteoclast differentiation. Taken together, these results strongly indicate that rebamipide mediates inhibitory effects on cartilage degradation and osteoclastogenesis in TMJ-OA. Results and Conclusion: Here, we highlight recent evidence regarding the potential for rebamipide to affect osteoclast differentiation and TMJ-OA pathogenesis. We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA. |
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| キーワード | ||||||||||||||||||
| 主題 | Rebamipide | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | osteoclast differentiation | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | ROS | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | chondrocyte | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | TMJ-OA | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | mitogen-activated | |||||||||||||||||
| 書誌情報 |
en : Current Rheumatology Reviews 巻 14, 号 1, p. 62-69, 発行日 2018 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 15733971 | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 18756360 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA12061959 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Bentham Science | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 権利情報 | This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 334344 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
