| Item type |
文献 / Documents(1) |
| 公開日 |
2019-10-02 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.14670/HH-26.147 |
|
|
言語 |
ja |
|
|
関連名称 |
10.14670/HH-26.147 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
N-cadherin expression in head and neck cancer |
|
言語 |
en |
| 著者 |
Nguyen, Phuong Thao
工藤, 保誠
ヨシダ, マキ
鎌田, 伸之
オガワ, イクコ
高田, 隆
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The loss of E-cadherin and the gain of N-cadherin expression are known as “cadherin switching”. Cadherin switching is a major hallmark of epithelial-mesenchymal transition (EMT). EMT is a crucial process in cancer progression, providing cancer cells with the ability to escape from the primary focus, to invade stromal tissues and to migrate to distant regions. Although down-regulation of E-cadherin is well known in various cancers, there are a few studies on N-cadherin expression in cancer. Here, therefore, we investigated whether N-cadherin expression was associated with the progression of head and neck squamous cell carcinoma (HNSCC). First, we examined the expression of N-cadherin by immunohistochemistry and its correlation with clinico-pathological findings. High expression of N-cadherin was observed in 52 of 80 HNSCC cases and was significantly correlated with malignant behaviors. Next, we examined the correlation between N-cadherin and E-cadherin. Cadherin switching (high expression of N-cadherin and low expression of E-cadherin) was found in 30 of 80 HNSCC cases and was well correlated with histological differentiation, pattern of invasion and lymph node metastasis in HNSCC cases. Moreover, we examined the expression of N-cadherin and E-cadherin by RT-PCR in 16 HNSCC cell lines to confirm the immunohistochemical findings. N-cadherin expression was observed in 7 of 16 HNSCC cells, and cadherin switching was observed in 2 HNSCC cells. Interestingly, HNSCC cells with cadherin switching have EMT features. In conclusion, we suggest that i) N-cadherin may play an important role in malignant behaviors of HNSCC, and ii) cadherin switching might be considered as a discrete critical event in EMT and metastatic potential of HNSCC. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
N-cadherin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
E-cadherin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
EMT |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Invasion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Head and neck squamous cell carcinoma |
| 書誌情報 |
en : Histology and Histopathology
巻 26,
号 2,
p. 147-156,
発行日 2010-12-13
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16995848 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
02133911 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10688044 |
| 出版者 |
|
|
出版者 |
University of Murcia |
|
言語 |
en |
| EID |
|
|
識別子 |
247610 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
hh_26_2_147.pdf (346 KB)
