| Item type |
文献 / Documents(1) |
| 公開日 |
2020-04-14 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1096/fj.201802724RR |
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|
言語 |
ja |
|
|
関連名称 |
10.1096/fj.201802724RR |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Iron accumulation causes impaired myogenesis correlated with MAPK signaling pathway inhibition by oxidative stress |
|
言語 |
en |
| 著者 |
池田, 康将
サトウ, アキホ
堀ノ内, 裕也
濱野, 裕章
ワタナベ, ヒロアキ
イマオ, ミズキ
今西, 正樹
座間味, 義人
武智, 研志
(井澤)石澤, 有紀
宮本, 理人
ヒラヤマ, タスク
永澤, 秀子
石澤, 啓介
粟飯原, 賢一
土屋, 浩一郎
玉置, 俊晃
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Skeletal muscle atrophy is caused by disruption in the homeostatic balance of muscle degeneration and regeneration under various pathophysiological conditions. We have previously reported that iron accumulation induces skeletal muscle atrophy via a ubiquitin ligase-dependent pathway. However, the potential effect of iron accumulation on muscle regeneration remains unclear. To examine the effect of iron accumulation on myogenesis, we used a mouse model with cardiotoxin (CTX)-induced muscle regeneration in vivo and C2C12 mice myoblast cells in vitro. In mice with iron overload, the skeletal muscles exhibited increased oxidative stress and decreased expression of satellite cell markers. Following CTX-induced muscle injury, these mice also displayed delayed muscle regeneration with a decrease in the size of regenerating myofibers, reduced expression of myoblast differentiation markers, and decreased phosphorylation of mitogen-activated protein kinase signaling pathways. In vitro, iron overload also suppressed the differentiation of C2C12 myoblast cells, but the suppression could be reversed by superoxide scavenging using tempol. Excess iron inhibits myogenesis via oxidative stress, leading to an imbalance in skeletal muscle homeostasis. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
muscle regeneration |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
muscle differentiation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
p38MAPK |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ERK1/2 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
iron |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
myogenesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oxidative stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mitogen-activated protein kinases(MAPKs) |
| 書誌情報 |
en : The FASEB Journal
巻 33,
号 8,
p. 9551-9564,
発行日 2019-05-30
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15306860 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
08926638 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1066874X |
| 出版者 |
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|
出版者 |
Federation of American Societies for Experimental Biology |
|
言語 |
en |
| 出版者 |
|
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出版者 |
John Wiley & Sons |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
This is the peer reviewed version of the following article: Ikeda, Y., Satoh, A., Horinouchi, Y., Hamano, H., Watanabe, H., Imao, M., Imanishi, M., Zamami, Y., Takechi, K., Izawa‐Ishizawa, Y., Miyamoto, L., Hirayama, T., Nagasawa, H., Ishizawa, K., Aihara, K.‐I., Tsuchiya, K. and Tamaki, T. (2019), Iron accumulation causes impaired myogenesis correlated with MAPK signaling pathway inhibition by oxidative stress. Faseb, 33: 9551-9564, which has been published in final form at https://doi.org/10.1096/fj.201802724RR. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| EID |
|
|
識別子 |
351099 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
faseb_33_8_9551.pdf (1.94 MB)
