| Item type |
文献 / Documents(1) |
| 公開日 |
2019-10-15 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1007/s00394-014-0749-1 |
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関連名称 |
10.1007/s00394-014-0749-1 |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice |
| 著者 |
タジマ, ソウイチロウ
池田, 康将
榎本, 英明
イマオ, ミズキ
堀ノ内, 裕也
(井澤)石澤, 有紀
木平, 孝高
宮本, 理人
石澤, 啓介
土屋, 浩一郎
玉置, 俊晃
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| 抄録 |
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内容記述 |
Purpose: Angiotensin II (ANG II) has been shown to affect iron metabolism through alteration of iron transporters, leading to increased cellular and tissue iron contents. Serum ferritin, a marker of body iron storage, is elevated in various cardiovascular diseases, including hypertension. However, the associated changes in iron absorption and the mechanism underlying increased iron content in a hypertensive state remain unclear.
Methods: C57BL6/J mice were treated with ANG II to generate a model of hypertension. Mice were divided into 3 groups: (1) control, (2) ANG II-treated, and (3) ANG II-treated and ANG II receptor blocker (ARB)-administered (ANG II-ARB) groups.
Results: Mice treated with ANG II showed increased serum ferritin levels compared to vehicle-treated control mice. In ANG II-treated mice, duodenal divalent metal transporter-1 (DMT1) and ferroportin (FPN) expression levels were increased and hepatic hepcidin mRNA expression and serum hepcidin concentration were reduced. The mRNA expression of bone morphogenetic protein 6 (BMP6) and CCAAT/enhancer binding protein alpha (C/EBPα), which are regulators of hepcidin, was also down-regulated in the livers of ANG II-treated mice. In terms of tissue iron content, macrophage iron content and renal iron content were increased by ANG II treatment, and these increases were associated with reduced expression of transferrin receptor 1 and FPN and increased expression of ferritin. These changes induced by ANG II treatment were ameliorated by administration of an ARB.
Conclusions: ANG II altered the expression of duodenal iron transporters and reduced hepcidin levels, contributing to the alteration of body iron distribution. |
| キーワード |
|
|
主題 |
Iron metabolism |
| キーワード |
|
|
主題 |
Angiotensin II |
| キーワード |
|
|
主題 |
Hepcidin |
| キーワード |
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|
主題 |
Ferritin |
| 書誌情報 |
en : European Journal of Nutrition
巻 54,
号 5,
p. 709-719,
発行日 2014-08-07
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14366207 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14366215 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11323696 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11622700 |
| 出版者 |
|
|
出版者 |
Springer Berlin Heidelberg |
| 備考 |
|
|
値 |
The final publication is available at link.springer.com. |
| EID |
|
|
識別子 |
280180 |
| 言語 |
|
|
言語 |
eng |
ejn_54_5_709.pdf (1.96 MB)
