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The Action of Smooth Muscle Cell Potassium Channels in the Pathology of Pulmonary Arterial Hypertension
https://tokushima-u.repo.nii.ac.jp/records/2006947
https://tokushima-u.repo.nii.ac.jp/records/2006947612ca400-3490-4c1f-a3df-901500951f00
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
pc_38_1_1.pdf (2.06 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2019-12-06 | |||||||||||
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| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1007/s00246-016-1491-7 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 10.1007/s00246-016-1491-7 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| タイトル | ||||||||||||
| タイトル | The Action of Smooth Muscle Cell Potassium Channels in the Pathology of Pulmonary Arterial Hypertension | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
早渕, 康信
× 早渕, 康信
WEKO
195
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Many different types of potassium channels with various functions exist in pulmonary artery smooth muscle cells, contributing to many physiological actions and pathological conditions. The deep involvement of these channels in the onset and exacerbation of pulmonary arterial hypertension (PAH) also continues to be revealed. In 2013, KCNK3 (TASK1), which encodes a type of two-pore domain potassium channel, was shown to be a predisposing gene for PAH by genetic mutation, and it was added to the PAH classification at the Fifth World Symposium on Pulmonary Hypertension (Nice International Conference). Decreased expression and inhibited activity of voltage-gated potassium channels, particularly KCNA5 (Kv1.5), are also seen in PAH, regardless of the cause, and facilitation of pulmonary arterial contraction and vascular remodeling has been shown. The calcium-activated potassium channels seen in smooth muscle cells also change from BKca (Kca1.1) to IKca (Kca3.1) predominance in PAH due to transformation, and have effects including the facilitation of smooth muscle cell migration, enhancement of proliferation, and inhibition of apoptosis. Elucidation of these roles for potassium channels in pulmonary vasoconstriction and remodeling may help bring new therapeutic strategies into view. | |||||||||||
| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Pulmonary arterial hypertension | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Potassium channel | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Smooth muscle cell | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Vascular remodeling | |||||||||||
| 書誌情報 |
en : Pediatric Cardiology 巻 38, 号 1, p. 1-14, 発行日 2016-11-08 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 01720643 | |||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 14321971 | |||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00361536 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Springer US | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | ja | |||||||||||
| 値 | This is a post-peer-review, pre-copyedit version of an article published in Pediatric Cardiology. The final authenticated version is available online at: https://doi.org/10.1007/s00246-016-1491-7. | |||||||||||
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| 識別子 | 324460 | |||||||||||
| 識別子タイプ | URI | |||||||||||
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| 言語 | eng | |||||||||||
