| Item type |
文献 / Documents(1) |
| 公開日 |
2019-12-12 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1093/ijnp/pyy013 |
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|
言語 |
ja |
|
|
関連名称 |
10.1093/ijnp/pyy013 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Plasma Levels of Soluble Tumor Necrosis Factor Receptor 2 (sTNFR2) Are Associated with Hippocampal Volume and Cognitive Performance in Patients with Schizophrenia |
|
言語 |
en |
| 著者 |
クドウ, ノリコ
ヤマモリ, ヒデナガ
イシマ, タマキ
ネモト, キヨタカ
ヤスダ, ユカ
フジモト, ミチコ
アゼチ, ヒロツグ
ニイツ, トミヒサ
沼田, 周助
イケダ, マナブ
イヨ, マサオミ
大森, 哲郎
フクナガ, マサキ
ワタナベ, ヨシユキ
ハシモト, ケンジ
ハシモト, リョウタ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: An imbalance in the inflammatory tumor necrosis factor system, including soluble tumor necrosis factor receptor 2 (sTNFR2), may contribute to the pathophysiology of schizophrenia.
Methods: We measured the plasma levels of sTNFR2 in 256 healthy controls and 250 patients with schizophrenia including antipsychotic drug-free patients and treatment-resistant patients. We also explored the possible association between plasma sTNFR2 levels and cognitive performance in healthy controls and patients with schizophrenia using the Wechsler Adult Intelligence Scale, Third Edition, the Wechsler Memory Scale-Revised, and the Rey Auditory Verbal Learning Test. An association between plasma sTNFR2 levels and hippocampal volume in controls and patients with schizophrenia was also investigated via MRI.
Results: We found that the plasma levels of sTNFR2 were significantly higher in patients with schizophrenia, including both antipsychotic drug-free patients and treatment-resistant patients. We found a significant negative association between plasma sTNFR2 levels and cognitive performance in controls and patients with schizophrenia. Hippocampal volume was also negatively associated with plasma sTNFR2 levels in patients with schizophrenia.
Conclusion: Together, these convergent data suggest a possible biological mechanism for schizophrenia, whereby increased sTNFR2 levels are associated with a smaller hippocampal volume and cognitive impairment. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
soluble tumor necrosis factor receptor 2 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cognitive performance |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hippocampal volume |
| 書誌情報 |
en : International Journal of Neuropsychopharmacology
巻 21,
号 7,
p. 631-639,
発行日 2018-02-24
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14611457 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14695111 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11545519 |
| 出版者 |
|
|
出版者 |
Oxford University Press |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| EID |
|
|
識別子 |
339432 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ijnp_21_7_631.pdf (2.16 MB)
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