| Item type |
文献 / Documents(1) |
| 公開日 |
2020-01-10 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.bbrc.2019.11.017 |
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関連名称 |
10.1016/j.bbrc.2019.11.017 |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
α-Tocopheryl succinate stabilizes the structure of tumor vessels by inhibiting angiopoietin-2 expression |
| 著者 |
ハマ, ススム
オカムラ, ユリコ
カメイ, カズホ
ナガオ, サキ
ハヤシ, マリ
マエダ, シズカ
福澤, 健治
小暮, 健太朗
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| 抄録 |
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内容記述 |
α-Tocopheryl succinate (TS) is a tocopherol derivative and has multifaceted anti-cancer effects; TS not only causes cancer cell-specific apoptosis but also inhibits tumor angiogenesis. Although TS has the potential to be used as a well-tolerated anti-angiogenic drug, it is still unclear which step of the angiogenic process is inhibited by TS. Here, we show that TS inhibits the expression of angiopoietin (Ang)-2, which induces destabilization of vascular structure in the initial steps of the angiogenic process. In mouse melanoma cells, TS treatment decreased mRNA and extracellular protein levels of Ang-2; however, the mRNA level of Ang-1, which stabilizes the vascular structure, remained unchanged. Furthermore, aorta ring and Matrigel plug angiogenesis assays indicated that the conditioned medium from TS-treated cells (CM-TS) inhibited neovascularization and blood leakage from the existing blood vessels, respectively. Following immunohistochemical staining of the vessels treated with CM-TS, imaging studies showed that the vascular endothelial cells were highly packed with pericytes. In conclusion, we found that TS inhibits Ang-2 expression and, consequently, stabilizes the vascular structure during the initial step of tumor angiogenesis. |
| キーワード |
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|
主題 |
Tocopheryl succinate |
| キーワード |
|
|
主題 |
Angiogenesis |
| キーワード |
|
|
主題 |
Angiopoietin |
| キーワード |
|
|
主題 |
Vascular stabilization |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 521,
号 4,
p. 947-951,
発行日 2019-11-11
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006291X |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11542044 |
| 出版者 |
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|
出版者 |
Elsevier |
| 権利情報 |
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|
権利情報 |
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
361352 |
| 言語 |
|
|
言語 |
eng |
bbrc_521_4_947.pdf (775 KB)
