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Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size
https://tokushima-u.repo.nii.ac.jp/records/2007248
https://tokushima-u.repo.nii.ac.jp/records/2007248e11c3fe9-a0e6-4390-a69c-6c2d1cfeee12
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jnsv_63_4_244.pdf (799 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2020-02-25 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3177/jnsv.63.244 | |||||||||||||||||||||||
| 関連名称 | 10.3177/jnsv.63.244 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein | |||||||||||||||||||||||
| 著者 |
バイヤルサイハナ, オド
× バイヤルサイハナ, オド
× 川合, 暢彦× 森, 博世× 木内, 奈央× 二川, 健
WEKO
1586
× 田中, 栄二
WEKO
323
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| 内容記述 | Myostatin, a member of the TGF-β superfamily, is a negative regulator of skeletal muscle cell growth and differentiation, and binds with high affinity to the activin type IIB receptor (ActRIIB). The soluble ligand-binding domain of ActRIIB fused to the Fc domain of IgG (ActRIIB-Fc) potently binds and inhibits TGF-β family members in muscle, leading to rapid and marked muscle growth. The present study was designed to assess the effectiveness of the co-delivery of myostatin-targeting siRNA (Mstn-siRNA) and ActRIIB-Fc into skeletal muscle as a potential treatment of atrophic myopathies. Eleven-week-old, male C57BL/6 mice were injected with atelocollagen (ATCOL)-mediated Mstn-siRNA with/without ActRIIB-Fc locally into the masseter muscle twice a week. Inhibition of myostatin function by the combination of Mstn-siRNA and ActRIIB-Fc increased muscle weight and myofibril size in murine masseter muscle. Real-time RT-PCR analysis revealed significant downregulation of myostatin mRNA expression in both the Mstn-siRNA-treated and the combination treatment group. Furthermore, myogenin mRNA expression was upregulated in the combination treatment group, while MuRF-1 and Atrogin-1 mRNA expression was downregulated compared to administration of each compound alone. These findings suggest that double inhibition of myostatin is a potentially useful treatment strategy to increase muscle mass and fiber size and could be a useful treatment of patients with various muscle atrophies, including muscular dystrophy. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | myostatin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | small-interfering RNAs | |||||||||||||||||||||||
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| 主題 | activin type IIB receptor | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | muscle hypertrophy | |||||||||||||||||||||||
| 書誌情報 |
en : Journal of Nutritional Science and Vitaminology 巻 63, 号 4, p. 244-248, 発行日 2017-10-04 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 03014800 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 18817742 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00703822 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | The Vitamin Society of Japan | |||||||||||||||||||||||
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| 出版者 | Japan Society of Nutrition and Food Science | |||||||||||||||||||||||
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| 出版者 | Center for Academic Publications Japan | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | © The Vitamin Society of Japan, Japan Society of Nutrition and Food Science 本文データは学協会の許諾に基づきCiNiiから複製したものである https://ci.nii.ac.jp/naid/130007314434 |
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| 識別子 | 334512 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
