| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2020-03-13 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1371/journal.ppat.1006955 |
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関連名称 |
10.1371/journal.ppat.1006955 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia |
| タイトル別表記 |
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その他のタイトル |
Clarithromycin expands CD11b+Gr-1+ MDSC-like cells |
| 著者 |
Namkoong, Ho
イシイ, マコト
藤猪, 英樹
ヤギ, カズマ
アサミ, タカヒロ
アサクラ, タカノリ
スズキ, ショウジ
Hegab, Ahmed E.
カマタ, ヒロフミ
タサカ, サダトモ
アタラシ, コウジ
ナカモト, ノブヒロ
イワタ, サトシ
ホンダ, ケンヤ
カナイ, タカノリ
ハセガワ, ナオキ
コヤス, シゲオ
ベツヤク, トモコ
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| 抄録 |
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内容記述 |
Macrolides are used to treat various inflammatory diseases owing to their immunomodulatory properties; however, little is known about their precise mechanism of action. In this study, we investigated the functional significance of the expansion of myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response to the macrolide antibiotic clarithromycin (CAM) in mouse models of shock and post-influenza pneumococcal pneumonia as well as in humans. Intraperitoneal administration of CAM markedly expanded splenic and lung CD11b+Gr-1+ cell populations in naïve mice. Notably, CAM pretreatment enhanced survival in a mouse model of lipopolysaccharide (LPS)-induced shock. In addition, adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice against LPS-induced lethality via increased IL-10 expression. CAM also improved survival in post-influenza, CAM-resistant pneumococcal pneumonia, with improved lung pathology as well as decreased interferon (IFN)-γ and increased IL-10 levels. Adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice from post-influenza pneumococcal pneumonia. Further analysis revealed that the CAM-induced CD11b+Gr-1+ cell expansion was dependent on STAT3-mediated Bv8 production and may be facilitated by the presence of gut commensal microbiota. Lastly, an analysis of peripheral blood obtained from healthy volunteers following oral CAM administration showed a trend toward the expansion of human MDSC-like cells (Lineage−HLA-DR−CD11b+CD33+) with increased arginase 1 mRNA expression. Thus, CAM promoted the expansion of a unique population of immunosuppressive CD11b+Gr-1+ cells essential for the immunomodulatory properties of macrolides. |
| 書誌情報 |
en : PLOS Pathogens
巻 14,
号 4,
p. e1006955,
発行日 2018-04-05
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15537366 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15537374 |
| 出版者 |
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出版者 |
PLOS |
| 権利情報 |
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権利情報 |
© 2018 Namkoong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
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識別子 |
344210 |
| 言語 |
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言語 |
eng |
plospathog_14_4_e1006955.pdf (10.8 MB)
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