| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-26 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1186/s41232-018-0075-8 |
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関連名称 |
10.1186/s41232-018-0075-8 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Considerations in hiPSC-derived cartilage for articular cartilage repair |
| 著者 |
ヤマシタ, アキヒロ
玉村, 禎宏
モリオカ, ミホ
Karagiannis, Peter
シマ, ノブユキ
ツマキ, ノリユキ
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| 抄録 |
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内容記述 |
Background: A lack of cell or tissue sources hampers regenerative medicine for articular cartilage damage.
Main text: We review and discuss the possible use of pluripotent stem cells as a new source for future clinical use. Human induced pluripotent stem cells (hiPSCs) have several advantages over human embryonic stem cells (hESCs). Methods for the generation of chondrocytes and cartilage from hiPSCs have been developed. To reduce the cost of this regenerative medicine, allogeneic transplantation is preferable. hiPSC-derived cartilage shows low immunogenicity like native cartilage, because the cartilage is avascular and chondrocytes are segregated by the extracellular matrix. In addition, we consider our experience with the aberrant deposition of lipofuscin or melanin on cartilage during the chondrogenic differentiation of hiPSCs.
Short conclusion: Cartilage generated from allogeneic hiPSC-derived cartilage can be used to repair articular cartilage damage. |
| キーワード |
|
|
主題 |
Chondrocytes |
| キーワード |
|
|
主題 |
Articular cartilage |
| キーワード |
|
|
主題 |
Regeneration |
| キーワード |
|
|
主題 |
Induced pluripotent stem cells |
| キーワード |
|
|
主題 |
Transplantation |
| 書誌情報 |
en : Inflammation and Regeneration
巻 38,
p. 17,
発行日 2018-10-04
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18808190 |
| 出版者 |
|
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出版者 |
BioMed Central |
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利情報 |
|
|
権利情報 |
© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| EID |
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|
識別子 |
357059 |
| 言語 |
|
|
言語 |
eng |
ir_38_17.pdf (2.46 MB)
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