| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-30 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1186/s41100-016-0048-9 |
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言語 |
ja |
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|
関連名称 |
10.1186/s41100-016-0048-9 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Evaluation of vascular quality of life questionnaire in dialysis patients with peripheral arterial disease treated by low-density lipoprotein apheresis |
|
言語 |
en |
| 著者 |
長井, 幸二郎
ハラダ, メグミ
ヨコタ, ナルシ
オカダ, ダイゴ
ミチワキ, ヒロユキ
ヒロセ, ダイスケ
土井, 俊夫
ミナクチ, ジュン
ツチダ, ケンジ
|
| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Peripheral arterial disease (PAD) is a common complication in dialysis patients. Early diagnosis and treatment are recommended. Low-density lipoprotein apheresis (LDL-A) is a potential therapy to improve PAD. However, the mechanism has yet to be fully clarified due to lack of established quantitative methods to assess the therapeutic effects of LDL-A treatment. Improvement of skin perfusion pressure (SPP) or ankle brachial index (ABI) is a representative therapy goal, but clinical symptoms were not always consistent with the values of SPP/ABI. Vascular quality of life questionnaire (VascuQOL) was proposed as a disease-specific QOL score, getting validated recently. The possibility of VascuQOL to reflect the severity of PAD in dialysis patients and evaluate the therapeutic effects of LDL-A has yet to be elucidated.
Methods: This is an observational study. LDL-A treatment was performed in 32 dialysis patients with PAD. They were divided to critical limb ischemia (CLI) group (17 subjects) and non-CLI group (15 subjects) according to their clinical manifestations. We examined the relationship of PAD severity with SPP, ABI, VascuQOL, and lipid profile such as apoB/apoA-I ratio, malondialdehyde-modified LDL, and remnant-like particles cholesterol. Furthermore, we evaluated these parameters successively to find out a suitable therapeutic marker just after the first LDL-A, at tenth LDL-A, and 1 month after completion of LDL-A treatment.
Results: All of the lipid markers were higher in CLI patients, but not significantly different from those in the non-CLI group. They decreased significantly just after LDL-A, although no changes were observed 1 month after completion of LDL-A treatment. ABI was significantly different between the CLI and non-CLI groups, but did not improve by LDL-A treatment. By contrast, SPP was ameliorated significantly and the peak was at tenth LDL-A. Among VascuQOL domains, “Symptom” and “Emotional” domains were significantly different between the CLI and non-CLI groups. The average score of VascuQOL increased successively until 1 month after completion of LDL-A treatment.
Conclusions: Several domains of VascuQOL can reflect the severity of PAD in dialysis patients. VascuQOL was a useful marker to show the prolonged therapeutic effects of LDL-A treatment in dialysis patients with PAD, independent of SPP. |
|
言語 |
en |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Vascular quality of life questionnaire (VascuQOL) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Peripheral arterial disease (PAD) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Low-density lipoprotein apheresis (LDL-A) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Skin perfusion pressure (SPP) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Ankle brachial index (ABI) |
| 書誌情報 |
en : Renal Replacement Therapy
巻 2,
p. 37,
発行日 2016-08-08
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20591381 |
| 出版者 |
|
|
出版者 |
BioMed Central |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| EID |
|
|
識別子 |
329374 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
rrt_2_37.pdf (568 KB)
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