| Item type |
文献 / Documents(1) |
| 公開日 |
2020-12-15 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.jphs.2018.11.009 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.jphs.2018.11.009 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats |
|
言語 |
en |
| 著者 |
アオヤマ, ブン
カワノ, タカシ
イワタ, ヒデキ
ニシガキ, アツシ
ヤマナカ, ダイキ
タテイワ, ヒロキ
シゲマツ, マリエ
江口, 覚
Locatelli, Fabricio M.
ヨコヤマ, マサタカ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The beneficial effects of physical activity for pain are denominated exercise-induced hypoalgesia (EIH). Here, we examined the age-related change and potential role of the neurosteroid allopregnanolone (ALLO) on EIH in rats. Adult and aged rats were randomly divided into one of three groups; non-exercise control, Low-exercise, and High-exercise. The animals in the Low- and High-exercise groups were subjected to a 10-minute treadmill workout at 40% and 80% maximum oxygen intake intensity, respectively. In the Low-exercise groups, a significant EIH response was observed in aged but not in adult rats. The pre-treatment with ALLO synthesis inhibitor finasteride, but not opioid-receptor antagonist naloxone, inhibited the Low-exercise induced EIH response in aged rats. Furthermore, the Low-exercise increased brain ALLO levels in aged animals compared with controls, which was correlated with the mechanical pain sensitivity. On the other hand, High-exercise could induce EIH response in both adult and aged animals, but it was more effective in adult rats. The pre-treatment with naloxone, but not finasteride, reduced the EIH observed after High-exercise in both adult and aged rats. Our findings demonstrated that effective EIH can be achieved even by mild-intensity exercise in aged animals via an increase of the brain ALLO levels. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neurosteroid |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Allopregnanolone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Aging |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Exercise |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Acute pain |
| 書誌情報 |
en : Journal of Pharmacological Sciences
巻 139,
号 2,
p. 77-83,
発行日 2018-11-30
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13478613 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Pharmacological Society |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
356594 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jphs_139_2_77.pdf (1.2 MB)
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