| Item type |
文献 / Documents(1) |
| 公開日 |
2020-07-16 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fcell.2014.00019 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3389/fcell.2014.00019 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Recruitment of bone marrow-derived cells to periodontal tissue defects |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
BMCs and periodontal tissue healing |
|
言語 |
en |
| 著者 |
キムラ, ヤスユキ
コマキ, モトヒロ
イワサキ, ケンゴ
佐田, 政隆
イズミ, ユウイチ
モリタ, イクオ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Bone marrow-derived cells (BMCs) are considered to be a major source of mesenchymal stem cells (MSCs) in adults and are known to be effective in periodontal tissue regeneration. However, whether endogenous BMCs are involved in periodontal tissue repair process is uncertain. We therefore created periodontal tissue defects in the buccal alveolar bone of mandibular first molars in bone marrow chimeric mice, and immunohistochemically examined the expression of stromal cell derived factor-1 (SDF-1) and the mobilization of BMCs. We found that SDF-1 expression was increased around the defects at as early as 1 week after injury and that BMCs were mobilized to the defects, while GFP+/CD45+ were rarely observed. Fluorescence-activated cell sorting (FACS) analysis demonstrated that the number of platelet-derived growth factor receptor (pdgfr) α+/Sca-1+ (PαS) cells in the bone marrow decreased after injury. Taken together, these results suggest that BMCs are mobilized to the periodontal tissue defects. Recruitment of BMCs, including a subset of MSCs could be a new target of periodontal treatment. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone marrow chimeric mice |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
periodontal defects |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mesenchymal stem cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
recruitment |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SDF-1 |
| 書誌情報 |
en : Frontiers in Cell and Developmental Biology
巻 2,
p. 19,
発行日 2014-05-21
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2296634X |
| 出版者 |
|
|
出版者 |
Frontiers Media S.A. |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2014 Kimura, Komaki, Iwasaki, Sata, Izumi and Morita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
277735 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
fcell_2_19.pdf (2.33 MB)
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