| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2147/COPD.S153750 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2147/COPD.S153750 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Relationship of annual change in bone mineral density with extent of emphysematous lesions and pulmonary function in patients with COPD |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Annual change in bone mineral density in COPD |
|
言語 |
en |
| 著者 |
ゴトウ, ケンイチ
オガワ, エミコ
シミズ, カオルコ
マキタ, ヒロニ
鈴木, 秀宣
河田, 佳樹
仁木, 登
ニシムラ, マサハル
ナカノ, ヤスタカ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Osteoporosis is a well-known comorbidity in COPD. It is associated with poor health status and prognosis. Although the exact pathomechanisms are unclear, osteoporosis is suggested to be either a comorbidity due to shared risk factors with COPD or a systematic effect of COPD with a cause–effect relationship. This study aimed to evaluate whether progression of osteoporosis is synchronized with that of COPD.
Materials and methods: Data from 103 patients with COPD included in the Hokkaido COPD cohort study were analyzed. Computed tomography (CT) attenuation values of thoracic vertebrae 4, 7, and 10 were measured using custom software, and the average value (average bone density; ABD4,7,10) was calculated. The percentage of low attenuation volume (LAV%) for each patient was also calculated for evaluation of emphysematous lesions. Annual change in thoracic vertebral CT attenuation, which is strongly correlated with dual-energy X-ray absorptiometry-measured bone mineral density, was compared with that in FEV1.0 or emphysematous lesions.
Results: In the first CT data set, ABD4,7,10 was significantly correlated with age (ρ=–0.331; p=0.0006), body mass index (BMI; ρ=0.246; p=0.0136), St George’s Respiratory Questionnaire (SGRQ) activity score (ρ=–0.248; p=0.0115), eosinophil count (ρ=0.229; p=0.0198), and LAV% (ρ=–0.372; p=0.0001). However, ABD4,7,10 was not associated with FEV1.0. After adjustment for age, BMI, SGRQ activity score, and eosinophil count, no significant relationship was found between ABD4,7,10 and LAV%. Annual change in ABD4,7,10 was not associated with annual change in LAV% or FEV1.0.
Conclusion: Progression of osteoporosis and that of COPD are not directly related or synchronized with each other. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
osteoporosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
quantitative CT analysis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
FEV1.0 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
low attenuation volume |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
automatic analysis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
systemic effect |
| 書誌情報 |
en : International Journal of Chronic Obstructive Pulmonary Disease
巻 13,
p. 639-644,
発行日 2018-02-20
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
11782005 |
| 出版者 |
|
|
出版者 |
Dove Medical Press |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2018 Goto et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
| EID |
|
|
識別子 |
336455 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
copd_13_639.pdf (716 KB)
.png)
