| Item type |
文献 / Documents(1) |
| 公開日 |
2020-12-25 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s41467-019-09867-7 |
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|
言語 |
ja |
|
|
関連名称 |
10.1038/s41467-019-09867-7 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation |
|
言語 |
en |
| 著者 |
ミヤカワ, ケイ
マツナガ, サトコ
ヨコヤマ, マサル
野間口, 雅子
キムラ, ヤヨイ
ニシ, マユコ
キムラ, ヒロカズ
サトウ, ヒロノリ
ヒラノ, ヒサシ
タムラ, トモヒコ
アカリ, ヒロフミ
ミウラ, トモユキ
足立, 昭夫
サワサキ, タツヤ
ヤマモト, ナオキ
リョウ, アキヒデ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we identify the PIM family of serine/threonine protein kinases as the factors responsible for the phosphorylation of Vpx and the promotion of Vpx-mediated SAMHD1 counteraction. Integrated proteomics and subsequent functional analysis reveal that PIM family kinases, PIM1 and PIM3, phosphorylate HIV-2 Vpx at Ser13 and stabilize the interaction of Vpx with SAMHD1 thereby promoting ubiquitin-mediated proteolysis of SAMHD1. Inhibition of the PIM kinases promotes the antiviral activity of SAMHD1, ultimately reducing viral replication. Our results highlight a new mode of virus–host cell interaction in which host PIM kinases facilitate promotion of viral infectivity by counteracting the host antiviral system, and suggest a novel therapeutic strategy involving restoration of SAMHD1-mediated antiviral response. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 10,
p. 1844,
発行日 2019-04-23
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20411723 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
|
|
識別子 |
354803 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ncomms_10_1844.pdf (1.88 MB)
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