| Item type |
文献 / Documents(1) |
| 公開日 |
2020-09-29 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s12022-020-09644-z |
|
|
言語 |
ja |
|
|
関連名称 |
10.1007/s12022-020-09644-z |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Immunohistochemistry or Molecular Analysis : Which Method Is Better for Subtyping Craniopharyngioma? |
|
言語 |
en |
| 著者 |
フクハラ, ノリアキ
岩田, 武男
イノシタ, ナオコ
吉本, 勝彦
キタガワ, マサノブ
フクハラ, ヒロカズ
タツシマ, ケイタ
ヤマグチ オカダ, ミツオ
タケシタ, アキラ
イトウ, ジュンコ
タケウチ, ヤスヒロ
山田, 正三
ニシオカ, ヒロシ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Craniopharyngioma (CP) is mainly classified into two pathological subtypes: adamantinomatous (ACP) and papillary (PCP). CTNNB1 (β-catenin) mutations are detected in ACPs, and the BRAF V600E mutation is detected in PCPs. However, genetic analysis is not always possible in general medical practice. In this study, we investigated whether immunohistochemistry could replace genetic analysis as an aid in subtype diagnosis. Here, 38 CP patients who had undergone their first tumor resection were included. Among the 38 cases, 22 were morphologically diagnosed as ACP, 10 cases were diagnosed as PCP, and six cases were diagnosed as undetermined CP that were morphologically difficult to classify as either ACP or PCP. Results of immunohistochemistry and genetic analysis and clinical features were compared. Based on the immunohistochemistry, 26 (22 ACPs and four undetermined CPs) showed nuclear β-catenin expression, 11 (nine PCPs and two undetermined CPs) exhibited positive BRAF V600E immunostaining and one PCP showed membranous β-catenin expression and negative for BRAF V600E immunostaining. Among the 26 nuclear β-catenin expression cases, 11 had CTNNB1 mutations; however, 15 cases had mutations of neither CTNNB1 nor BRAF V600E. All 11 BRAF V600E immunopositive cases had BRAF V600E mutations. When comparing clinical features between, pediatric patients and those with tumor calcification and less solid components on MRI more commonly had nuclear β-catenin expression tumors than BRAF V600E immunopositive tumors, reflecting the differences in clinical features between ACP and PCP. Accordingly, immunohistochemistry can replace genetic analysis as an aid to determine the subtype diagnosis of CP in general medical practice. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Craniopharyngioma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CTNNB1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
β-Catenin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BRAF V600E |
| 書誌情報 |
en : Endocrine Pathology
巻 32,
号 2,
p. 262-268,
発行日 2020-09-23
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15590097 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10463976 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10803175 |
| 出版者 |
|
|
出版者 |
Springer Science+Business Media |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
This is a post-peer-review, pre-copyedit version of an article published in Endocrine Pathology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12022-020-09644-z. |
| EID |
|
|
識別子 |
371551 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ep_32_2_262.pdf (545 KB)
