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Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

https://tokushima-u.repo.nii.ac.jp/records/2008521
https://tokushima-u.repo.nii.ac.jp/records/2008521
a42d3810-f807-4315-b23a-0a693308126c
名前 / ファイル ライセンス アクション
ncomms_11_2198.pdf ncomms_11_2198.pdf (3.4 MB)
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Item type 文献 / Documents(1)
公開日 2021-02-10
アクセス権
アクセス権 open access
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版社版DOI
関連識別子 https://doi.org/10.1038/s41467-020-16041-x
関連名称 10.1038/s41467-020-16041-x
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
タイトル
タイトル Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
著者 Lucas, Beth

× Lucas, Beth

en Lucas, Beth

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White, Andrea J.

× White, Andrea J.

en White, Andrea J.

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Cosway, Emilie J.

× Cosway, Emilie J.

en Cosway, Emilie J.

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Parnell, Sonia M.

× Parnell, Sonia M.

en Parnell, Sonia M.

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James, Kieran D.

× James, Kieran D.

en James, Kieran D.

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Jones, Nick D.

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en Jones, Nick D.

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大東, いずみ

× 大東, いずみ

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徳島大学 教育研究者総覧 207340/profile-ja.html
e-Rad 00596588

ja 大東, いずみ
ISNI

ja-Kana オオヒガシ, イズミ

en Ohigashi, Izumi

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高浜, 洋介

× 高浜, 洋介

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徳島大学 教育研究者総覧 60028/profile-ja.html
e-Rad 20183858

ja 高浜, 洋介
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ja-Kana タカハマ, ヨウスケ

en Takahama, Yousuke

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Jenkinson, William E.

× Jenkinson, William E.

en Jenkinson, William E.

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Anderson, Graham

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抄録
内容記述 The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly understood. Here we examine medullary thymic epithelial cell (mTEC) heterogeneity and its influence on CD1d-restricted iNKT cells. We find three distinct mTEClow subsets distinguished by surface, intracellular and secreted molecules, and identify LTβR as a cell-autonomous controller of their development. Importantly, this mTEC heterogeneity enables the thymus to differentially control iNKT sublineages possessing distinct effector properties. mTEC expression of LTβR is essential for the development thymic tuft cells which regulate NKT2 via IL-25, while LTβR controls CD104+ CCL21+ mTEClow that are capable of IL-15-transpresentation for regulating NKT1 and NKT17. Finally, mTECs regulate both iNKT-mediated activation of thymic dendritic cells, and iNKT availability in extrathymic sites. In conclusion, mTEC specialization controls intrathymic iNKT cell development and function, and determines iNKT pool size in peripheral tissues.
書誌情報 en : Nature Communications

巻 11, p. 2198, 発行日 2020-05-04
収録物ID
収録物識別子タイプ ISSN
収録物識別子 20411723
収録物ID
収録物識別子タイプ NCID
収録物識別子 AA12645905
出版者
出版者 Springer Nature
権利情報
権利情報 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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識別子 366474
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言語 eng
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