| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-16 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/ijms17060954 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/ijms17060954 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Roles of PTEN with DNA Repair in Parkinson’s Disease |
|
言語 |
en |
| 著者 |
オギノ, マコ
(市村)清水, 真祐子
ナカノ, ノリコ
ミナミ, アカリ
キタギシ, ヤスコ
マツダ, サトル
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Oxidative stress is considered to play key roles in aging and pathogenesis of many neurodegenerative diseases such as Parkinson’s disease, which could bring DNA damage by cells. The DNA damage may lead to the cell apoptosis, which could contribute to the degeneration of neuronal tissues. Recent evidence suggests that PTEN (phosphatase and tensin homolog on chromosome 10) may be involved in the pathophysiology of the neurodegenerative disorders. Since PTEN expression appears to be one dominant determinant of the neuronal cell death, PTEN should be a potential molecular target of novel therapeutic strategies against Parkinson’s disease. In addition, defects in DNA damage response and DNA repair are often associated with modulation of hormone signaling pathways. Especially, many observations imply a role for estrogen in a regulation of the DNA repair action. In the present review, we have attempted to summarize the function of DNA repair molecules at a viewpoint of the PTEN signaling pathway and the hormone related functional modulation of cells, providing a broad interpretation on the molecular mechanisms for treatment of Parkinson’s disease. Particular attention will be paid to the mechanisms proposed to explain the health effects of food ingredients against Parkinson’s disease related to reduce oxidative stress for an efficient therapeutic intervention. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oxidative stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ROS |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
DNA repair |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PTEN |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BRCA1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
estrogen |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Parkinson’s disease |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 17,
号 6,
p. 954,
発行日 2016-06-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14220067 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16616596 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12038549 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
369429 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ijms_17_6_954.pdf (496 KB)
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