| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-16 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/ijms21061906 |
|
|
関連名称 |
10.3390/ijms21061906 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering |
| 著者 |
フルカワ, コウイチ
オオウミ, ユウスケ
Yesmin, Farhana
タジマ, オリエ
コンドウ, ユウジ
Zhang, Pu
橋本, 登
オオカワ, ユウキ
Bhuiyan, Robiul H.
フルカワ, ケイコ
|
| 抄録 |
|
|
内容記述 |
Acidic glycosphingolipids, i.e., gangliosides, are predominantly and consistently expressed in nervous tissues of vertebrates at high levels. Therefore, they are considered to be involved in the development and function of nervous systems. Recent studies involving genetic engineering of glycosyltransferase genes have revealed novel aspects of the roles of gangliosides in the regulation of nervous tissues. In this review, novel findings regarding ganglioside functions and their modes of action elucidated mainly by studies of gene knockout mice are summarized. In particular, the roles of gangliosides in the regulation of lipid rafts to maintain the integrity of nervous systems are reported with a focus on the roles in the regulation of neuro-inflammation and neurodegeneration via complement systems. In addition, recent advances in studies of congenital neurological disorders due to genetic mutations of ganglioside synthase genes and also in the techniques for the analysis of ganglioside functions are introduced. |
| キーワード |
|
|
主題 |
ganglioside |
| キーワード |
|
|
主題 |
knockout |
| キーワード |
|
|
主題 |
neurodegeneration |
| キーワード |
|
|
主題 |
glycosphingolipid |
| キーワード |
|
|
主題 |
inflammation |
| キーワード |
|
|
主題 |
microdomain |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 21,
号 6,
p. 1906,
発行日 2020-03-11
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14220067 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16616596 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12038549 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
381472 |
| 言語 |
|
|
言語 |
eng |
ijms_21_6_1906.pdf (1.42 MB)
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