| Item type |
文献 / Documents(1) |
| 公開日 |
2021-03-24 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2147/NDT.S238471 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2147/NDT.S238471 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
ABCA7 Gene Expression and Genetic Association Study in Schizophrenia |
|
言語 |
en |
| 著者 |
ヤマザキ, キヨヒロ
ヨシノ, ユウタ
カワベ, ケンタロウ
イブキ, トモマサ
オチ, シンイチロウ
モリ, ヨウコ
オザキ, ユウキ
沼田, 周助
伊賀, 淳一
大森, 哲郎
上野, 修一
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Introduction: Although ATP-binding cassette sub-family A member 7 gene (ABCA7) is known to be associated with Alzheimer’s disease, the relationship between ABCA7 and schizophrenia has been unknown.
Methods: Schizophrenia patients (n = 50; 24 males, 62.1 ± 0.50 years old) and age- and sex-matched healthy controls (n = 50) were recruited for the mRNA analysis. Additionally, a case-control study for the rs3764650 genotypes was performed with 1308 samples (control subjects; n = 527, schizophrenia patients; n = 781). All participants were Japanese, unrelated to each other, and living in the same area.
Results: The distributions of the rs3764650 genotypes in schizophrenia patients were not different from that of controls. However, the ABCA7 mRNA expression levels in schizophrenia patients were significantly higher than those in controls by a logistic regression analysis. Additionally, the ABCA7 mRNA expression levels in schizophrenia patients were correlated with the rs3764650 genotypes in a dose-dependent manner.
Discussion: The ABCA7 mRNA expression levels in peripheral blood with the rs3764650 genotypes may be related to pathological mechanisms in schizophrenia and may be a biological marker for schizophrenia. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
schizophrenia |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ATP-binding cassette sub-family A member 7 gene |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
single nucleotide polymorphism |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
rs3764650 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mRNA expression |
| 書誌情報 |
en : Neuropsychiatric Disease and Treatment
巻 16,
p. 441-446,
発行日 2020-02-13
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
11782021 |
| 出版者 |
|
|
出版者 |
Dove Medical Press |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2020 Yamazaki et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
| EID |
|
|
識別子 |
365485 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ndt_16_441.pdf (1.28 MB)
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