| Item type |
文献 / Documents(1) |
| 公開日 |
2021-04-20 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1002/npr2.12083 |
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関連名称 |
10.1002/npr2.12083 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Structural variation in the glycogen synthase kinase 3β and brain‐derived neurotrophic factor genes in Japanese patients with bipolar disorders |
| 著者 |
スガ, ヨウスケ
ヨシモト, ケイイチロウ
沼田, 周助
シモデラ, シンジ
タカムラ, ショウゴ
カミムラ, ナオト
サワダ, ケン
カズイ, ヒロミツ
大森, 哲郎
モリノブ, シゲル
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| 抄録 |
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内容記述 |
Background: Lithium is the first‐line drug for the treatment of bipolar disorders (BDs); however, not all patients responded. Glycogen synthase kinase (GSK) 3β and brain‐derived neurotrophic factor (BDNF) play a role in the therapeutic action of lithium. Since structural variations were reported in these genes, it is possible that these genomic variations may be involved in the therapeutic responses to lithium.
Method: Fifty patients with BDs and 50 healthy subjects (mean age 55.0 ± 15.0 years; M/F 19/31) participated. We examined structural variation of the GSK3β and BDNF genes by real‐time PCR. We examined the influence of structural variation of these genes on the therapeutic responses to lithium and the occurrence of antidepressant‐emergent affective switch (AEAS). The efficacy of lithium was assessed using the Alda scale, and AEAS was evaluated using Young Mania Rating Scale.
Results: Although we examined structural variations within intron II and VII of the GSK3® gene and from the end of exon IV to intron IV and within exon IX of the BDNF gene, no structural variation was found in BDs. Whereas 5 of 50 patients exhibited three copies of the genomic region within exon IV of the BDNF gene, all healthy subjects had two copies. No difference in the therapeutic efficacy of lithium was found between patients with three and two copies. No difference in the occurrence of AEAS was found between the two groups.
Conclusion: The amplification of the BDNF gene influenced neither the therapeutic responses to lithium nor the occurrence of AEAS. |
| キーワード |
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主題 |
bipolar disorder |
| キーワード |
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主題 |
brain‐derived neurotrophic factor |
| キーワード |
|
|
主題 |
copy number variation |
| キーワード |
|
|
主題 |
glycogen synthase kinase 3® |
| キーワード |
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|
主題 |
lithium |
| 書誌情報 |
en : Neuropsychopharmacology Reports
巻 40,
号 1,
p. 46-51,
発行日 2019-11-26
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2574173X |
| 出版者 |
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出版者 |
The Japanese Society of Neuropsychopharmacology |
| 出版者 |
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出版者 |
John Wiley & Sons |
| 備考 |
|
|
値 |
所属英表記誤記あり (誤)Watarigawa Hostipal→(正)Watarigawa Hospital |
| 権利情報 |
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|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
361876 |
| 言語 |
|
|
言語 |
eng |
npr_40_1_46.pdf (492 KB)
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