| Item type |
文献 / Documents(1) |
| 公開日 |
2021-07-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3892/ol.2018.9188 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3892/ol.2018.9188 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Stereotactic body radiotherapy for centrally‑located lung tumors with 56 Gy in seven fractions : A retrospective study |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
SBRT FOR CENTRAL LUNG TUMORS WITH 56 Gy/7 fr |
|
言語 |
en |
| 著者 |
アオキ, シュリ
ヤマシタ, ヒデオミ
芳賀, 昭弘
オオタ, タケシ
タカハシ, ワタル
オザキ, ショウ
ナワ, カナブ
イマエ, トシカズ
アベ, オサム
ナカガワ, ケイイチ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Stereotactic body radiotherapy (SBRT) for centrally‑located lung tumors remains a challenge because of the increased risk of treatment‑related adverse events (AEs), and uncertainty around prescribing the optimal dose. The present study reported the results of central tumor SBRT with 56 Gy in 7 fractions (fr) at the University of Tokyo Hospital. A total of 35 cases that underwent SBRT with or without volumetric‑modulated arc therapy consisting of 56 Gy/7 fr for central lung lesions between 2010 and 2016 at the University of Tokyo Hospital were reveiwed. A central lesion was defined as a tumor within 2 cm of the proximal bronchial tree (RTOG 0236 definition) or within 2 cm in all directions of any critical mediastinal structure. Local control (LC), overall survival (OS), and AEs were investigated. The Kaplan‑Meier method was used to estimate LC and OS. AEs were scored per the Common Terminology Criteria for Adverse Events Version 4.0. Thirty‑five patients with 36 central lung lesions were included. Fifteen lesions were primary non‑small cell lung cancer (NSCLC), 13 were recurrences of NSCLC, and 8 had oligo‑recurrences from other primaries. Median tumor diameter was 29 mm. Eighteen patients had had prior surgery. At a median follow‑up of 13.1 months for all patients and 18.3 months in surviving patients, 22 patients had died, ten due to primary disease (4 NSCLC), while three were treatment‑related. The 1‑ and 2‑year OS were 57.3 and 40.4%, respectively, and median OS was 15.7 months. Local recurrence occurred in only two lesions. 1‑ and 2‑year LC rates were both 96%. Nine patients experienced grade ≥3 toxicity, representing 26% of the cohort. Two of these were grade 5, one pneumonitis and one hemoptysis. Considering the background of the subject, tumor control of our central SBRT is promising, especially in primary NSCLC. However, the safety of SBRT to central lung cancer remains controversial. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
central lung tumor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
stereotactic body radiotherapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
volumetric modulated arc therapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lung cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
radiation pneumonitis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
pulmonary oligo‑recurrence |
| 書誌情報 |
en : Oncology Letters
巻 16,
号 4,
p. 4498-4506,
発行日 2018-07-23
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17921074 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17921082 |
| 出版者 |
|
|
出版者 |
Spandidos Publications |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. |
| EID |
|
|
識別子 |
345645 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ol_16_4_4498.pdf (991 KB)
.png)
