| Item type |
文献 / Documents(1) |
| 公開日 |
2021-05-21 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s00595-019-01787-9 |
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言語 |
ja |
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|
関連名称 |
10.1007/s00595-019-01787-9 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Daikenchuto accelerates the recovery from prolonged postoperative ileus after open abdominal surgery : a subgroup analysis of three randomized controlled trials |
|
言語 |
en |
| 著者 |
コウノ, トオル
島田, 光生
西, 正暁
森根, 裕二
吉川, 幸造
カツノ, ヒデトシ
マエダ, コウタロウ
コエダ, ケイスケ
モリタ, サトシ
渡邊, 正彦
クサノ, ミツオ
サカモト, ジュンイチ
サジ, シゲトヨ
ソクオカ, ヒロキ
サトウ, ヤスト
マエハラ, ヨシヒコ
カネマツ, タカシ
キタジマ, マサキ
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Purpose
Prolonged postoperative ileus (POI) is a common complication after open abdominal surgery (OAS). Daikenchuto (DKT), a traditional Japanese medicine that peripherally stimulates the neurogenic pathway, is used to treat prolonged POI in Japan. To analyze whether DKT accelerates the recovery from prolonged POI after OAS, we conducted a secondary analysis of three multicenter randomized controlled trials (RCTs).
Methods
A secondary analysis of the three RCTs supported by the Japanese Foundation for Multidisciplinary Treatment of Cancer (project numbers 39-0902, 40-1001, 42-1002) assessing the effect of DKT on prolonged POI in patients who had undergone OAS for colon, liver, or gastric cancer was performed. The subgroup included 410 patients with no bowel movement (BM) before the first diet, a DKT group (n = 214), and a placebo group (n = 196). Patients received either 5 g DKT or a placebo orally, three times a day. The primary endpoint was defined as the time from the end of surgery to the first bowel movement (FBM). A sensitivity analysis was also performed on the age, body mass index and dosage as subgroup analyses.
Results
The primary endpoint was significantly accelerated in the DKT group compared with the placebo group (p = 0.004; hazard ratio 1.337). The median time to the FBM was 113.8 h in the placebo group and 99.1 h in the DKT treatment group.
Conclusions
The subgroup analysis showed that DKT significantly accelerated the recovery from prolonged POI following OAS. |
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言語 |
en |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Kampo |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Body mass index |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Postoperative ileus |
| 書誌情報 |
en : Surgery Today
巻 49,
号 8,
p. 704-711,
発行日 2019-02-25
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
09411291 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14362813 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10824685 |
| 出版者 |
|
|
出版者 |
Japan Surgical Society |
|
言語 |
en |
| 出版者 |
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出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| EID |
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識別子 |
361184 |
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識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
st_49_8_704.pdf (436 KB)
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