| Item type |
文献 / Documents(1) |
| 公開日 |
2021-06-01 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1128/JVI.01324-19 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1128/JVI.01324-19 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Tracking the Fate of Endogenous Retrovirus Segregation in Wild and Domestic Cats |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Fate of an Infectious ERV in Wild and Domestic Cats |
|
言語 |
en |
| 著者 |
Ngo, Minh Ha
Arnal, MaríaCruz
スミ, リョウスケ
カワサキ, ジュンナ
三宅, 在子
Grant, Chris K.
音井, 威重
de Luco, Daniel Fernández
ニシガキ, カズオ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Endogenous retroviruses (ERVs) of domestic cats (ERV-DCs) are one of the youngest feline ERV groups in domestic cats (Felis silvestris catus); some members are replication competent (ERV-DC10, ERV-DC18, and ERV-DC14), produce the antiretroviral soluble factor Refrex-1 (ERV-DC7 and ERV-DC16), or can generate recombinant feline leukemia virus (FeLV). Here, we investigated ERV-DC in European wildcats (Felis silvestris silvestris) and detected four loci: ERV-DC6, ERV-DC7, ERV-DC14, and ERV-DC16. ERV-DC14 was detected at a high frequency in European wildcats; however, it was replication defective due to a single G → A nucleotide substitution, resulting in an E148K substitution in the ERV-DC14 envelope (Env). This mutation results in a cleavage-defective Env that is not incorporated into viral particles. Introduction of the same mutation into feline and murine infectious gammaretroviruses resulted in a similar Env dysfunction. Interestingly, the same mutation was found in an FeLV isolate from naturally occurring thymic lymphoma and a mouse ERV, suggesting a common mechanism of virus inactivation. Refrex-1 was present in European wildcats; however, ERV-DC16, but not ERV-DC7, was unfixed in European wildcats. Thus, Refrex-1 has had an antiviral role throughout the evolution of the genus Felis, predating cat exposure to feline retroviruses. ERV-DC sequence diversity was present across wild and domestic cats but was locus dependent. In conclusion, ERVs have evolved species-specific phenotypes through the interplay between ERVs and their hosts. The mechanism of viral inactivation may be similar irrespective of the evolutionary history of retroviruses. The tracking of ancestral retroviruses can shed light on their roles in pathogenesis and host-virus evolution. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ERV-DC |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
endogenous retrovirus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Fv-4 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
FeLV |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Felis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
MuLV |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
domestic cat |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
domestication |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
evolution |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
wildcat |
| 書誌情報 |
en : Journal of Virology
巻 93,
号 24,
p. e01324-19,
発行日 2019-11-26
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10985514 |
| 出版者 |
|
|
出版者 |
American Society for Microbiology |
|
言語 |
en |
| EID |
|
|
識別子 |
370230 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
JVI_93_24_e01324-19.pdf (5.31 MB)
