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Development of Novel Analysis and Characterization Methods Utilizing Reaction Dynamics in a Separation Capillary
https://tokushima-u.repo.nii.ac.jp/records/2009579
https://tokushima-u.repo.nii.ac.jp/records/20095790f18691e-b98a-4085-bf8b-10348db88ea6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jpchrom_43_1_1.pdf (538 KB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2022-03-31 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.15583/jpchrom.2021.022 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 10.15583/jpchrom.2021.022 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| タイトル | ||||||||||||
| タイトル | Development of Novel Analysis and Characterization Methods Utilizing Reaction Dynamics in a Separation Capillary | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
髙栁, 俊夫
× 髙栁, 俊夫
WEKO
549
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Electrophoretic migration of an analyte in capillary electrophoresis (CE) reflects reaction dynamics of the analyte in solution. In affinity CE, an analyte of interest interacts with a modifier added in the separation buffer in fast equilibrium, and effective electrophoretic mobility of the analyte is contributed from its equilibrium species. Precise measurement of effective electrophoretic mobility allows analyzing the equilibrium. Analysis of equilibria under CE separation possesses several advantages against traditional analyses in homogeneous solution; coexisting substances including impurities and kinetically generated substances are resolved by CE from the equilibrium species of interest. Characteristics of the CE analysis have been applied to analyses of acid-base equilibria of degradable substances and ion-association equilibria in an aqueous solution. Since CE is operated in an open-tubular capillary, it is also suitable for the characterization of carbon nanoclusters such as graphene and carbon nanotube, and measurement of effective electrophoretic mobility helps characterization of nanoclusters. A novel analysis technique of capillary electrophoresis/dynamic frontal analysis (CE/DFA) has also been proposed for the analysis of such reactions as involving equilibria and kinetic reactions. In CE/DFA, kinetically generated product is continuously resolved from the equilibrium species, and a plateau signal would be detected when the reaction rate is constant. Michaelis-Menten constants have successfully been determined through the plateau height by CE/DFA. In this review, analysis and characterization methods utilizing reaction dynamics in a separation capillary are summarized. | |||||||||||
| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Capillary electrophoresis | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Degradable substances | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Ion-association equilibria | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Carbon nanoclusters | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Enzyme assay | |||||||||||
| 書誌情報 |
en : Chromatography 巻 43, 号 1, p. 1-14, 発行日 2022-02-20 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 13483315 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 13428284 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA1137755X | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | The Society for Chromatographic Sciences | |||||||||||
| 言語 | en | |||||||||||
| EID | ||||||||||||
| 識別子 | 383743 | |||||||||||
| 識別子タイプ | URI | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
