| Item type |
文献 / Documents(1) |
| 公開日 |
2022-02-21 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/cells10123513 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/cells10123513 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism |
|
言語 |
en |
| 著者 |
アズマ, ヤスタカ
フジタ, タカシ
イザワ, タケシ
ヒロタ, カナ
ニシヤマ, カズヒロ
イケガミ, アイリ
アオヤマ, トモコ
イケ, ミキヒト
ウシカイ, ユミ
クワムラ, ミツル
フジイ, ヒデキ
常山, 幸一
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Interleukin (IL)-19, a member of the IL-10 family, is an anti-inflammatory cytokine produced primarily by macrophages. Nonalcoholic steatohepatitis (NASH) is a disease that has progressed from nonalcoholic fatty liver disease (NAFLD) and is characterized by inflammation and fibrosis. We evaluated the functions of IL-19 in a NAFLD/NASH mouse model using a 60% high fat diet with 0.1% methionine, without choline, and with 2% cholesterol (CDAHFD). Wild-type (WT) and IL-19 gene-deficient (KO) mice were fed a CDAHFD or standard diet for 9 weeks. Liver injury, inflammation, and fibrosis induced by CDAHFD were significantly worse in IL-19 KO mice than in WT mice. IL-6, TNF-α, and TGF-β were significantly higher in IL-19 KO mice than in WT mice. As a mechanism using an in vitro experiment, palmitate-induced triglyceride and cholesterol contents were decreased by the addition of IL-19 in HepG2 cells. Furthermore, addition of IL-19 decreased the expression of fatty acid synthesis-related enzymes and increased ATP content in HepG2 cells. The action of IL-19 in vitro suppressed lipid metabolism. In conclusion, IL-19 may play an important role in the development of steatosis and fibrosis by directly regulating liver metabolism and may be a potential target for the treatment of liver diseases. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-19 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
NAFLD |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
NASH |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inflammation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
liver |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lipogenesis |
| 書誌情報 |
en : Cells
巻 10,
号 12,
p. 3513,
発行日 2021-12-13
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20734409 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
384228 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
cells_10_12_3513.pdf (2.19 MB)
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