| Item type |
文献 / Documents(1) |
| 公開日 |
2022-04-15 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1002/ppap.201900257 |
|
|
関連名称 |
10.1002/ppap.201900257 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Continuous release of O2−/ONOO− in plasma-exposed HEPES-buffered saline promotes TRP channel-mediated uptake of a large cation |
| 著者 |
ササキ, ショウタ
Zheng, Yuexing
モクダイ, タカユキ
カネタカ, ヒロヤス
立川, 正憲
カンザキ, マコト
カネコ, トシロウ
|
| 抄録 |
|
|
内容記述 |
Although the externally controllable extracellular supply of the short-lived reactive oxygen and nitrogen species, such as O2•−, •NO, and ONOO−, could potentially manipulate cellular functions, their simple administration to cells is likely to be ineffective due to their rapid deactivation. In this study, we found a method of a continuous supply of O2•−/ONOO− over a few minutes, which is triggered by irradiation of a nonequilibrium atmospheric pressure plasma to commonly used organic buffers (e.g., 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, HEPES). In addition, a continuous low-dose O2•−/ONOO− supply was shown to induce a physiologically relevant Ca2+ response and subsequently the uptake of a large cation mediated by transient receptor potential channel family member(s). Our results provide a novel approach to the continuous O2•−/ONOO− supply, requiring controllable and mass-volume treatments. |
| キーワード |
|
|
主題 |
atmospheric pressure plasma |
| キーワード |
|
|
主題 |
Ca2+ signaling |
| キーワード |
|
|
主題 |
peroxynitrite |
| キーワード |
|
|
主題 |
plasma medicine |
| キーワード |
|
|
主題 |
TRP channel |
| 書誌情報 |
en : Plasma Processes and Polymers
巻 17,
号 10,
p. e1900257,
発行日 2020-05-25
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16128869 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11976237 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1281120X |
| 出版者 |
|
|
出版者 |
Wiley‐VCH |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
381692 |
| 言語 |
|
|
言語 |
eng |
ppap_17_10_e1900257.pdf (1.59 MB)
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