| Item type |
文献 / Documents(1) |
| 公開日 |
2022-05-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.tige.2021.10.001 |
|
|
関連名称 |
10.1016/j.tige.2021.10.001 |
| 出版タイプ |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
|
|
タイトル |
Small Intestinal Involvement and Genotype-Phenotype Correlation in Familial Adenomatous Polyposis |
| タイトル別表記 |
|
|
その他のタイトル |
家族性大腸腺腫症における小腸病変と遺伝型-表現型の関係 |
| タイトル別表記 |
|
|
その他のタイトル |
Small Intestinal Involvement in FAP |
| 著者 |
田中, 久美子
佐藤, 康史
イシカワ, ヒデキ
六車, 直樹
寺前, 智史
タケウチ, ヨウジ
三井, 康裕
岡本, 耕一
宮本, 弘志
坂東, 良美
ソノダ, トモコ
オオミヤ, ナオキ
ムトウ, ミチヒロ
高山, 哲治
|
| 抄録 |
|
|
内容記述 |
BACKGROUND AND AIMS: Small intestinal involvement in familial adenomatous polyposis (FAP) remains unclarified. We performed capsule endoscopy (CE) and balloon-assisted (BA) endoscopy to analyze small intestinal polyps and their genotype-phenotype correlations in a large cohort of FAP patients.
METHODS: In this retrospective study, we performed CE in all 149 FAP patients and BA endoscopy in 74 patients with larger polyps. The prevalence of small intestinal adenoma with high-grade dysplasia and cancer was investigated. Correlation between APC variant and polyp phenotype was analyzed.
RESULTS: Median patient age was 44 years and 69% were male. Pathogenic germline APC variants were found in 117/136 (86.1%). Overall prevalence and median number of small intestinal polyps were 85.2% (127/149) and 17 (IQR 6-36), respectively. A total of 5318 polyps were detected by CE and all 433 polyps histologically examined were confirmed as adenoma. The number of polyps significantly decreased from the proximal-to-distal tracts. Adenoma with high-grade dysplasia was detected in 26.2% (39/149), and its incidence among the polyps was approximately 1.4% (74/5318). Of these, 14 were intramucosal carcinomas with a prevalence of 5.4% (8/149). The germline APC variant in codon 1251-1580 was significantly correlated with a high number of small intestinal polyps. Multivariate analysis revealed APC variant in codon 1251-1580 and a high number of small intestinal polyps as independent risk factors for adenoma with high-grade dysplasia. Spigelman stage was significantly associated with number of jejunal/ileal polyps and their high-grade dysplasia.
CONCLUSION: Among FAP patients, small intestinal adenoma with high-grade dysplasia was detected in 26.2% and cancer in 5.4%. FAP patients, particularly those with APC variant in codon 1251-1580 and/or high Spigelman stage may require surveillance for small intestinal polyps. |
| キーワード |
|
|
主題 |
FAP |
| キーワード |
|
|
主題 |
small intestinal polyps |
| キーワード |
|
|
主題 |
capsule endoscopy |
| キーワード |
|
|
主題 |
APC |
| キーワード |
|
|
主題 |
adenoma with high-grade dysplasia |
| キーワード |
|
|
主題 |
Multivariate logistic analysis |
| キーワード |
|
|
主題 |
Spigelman score |
| キーワード |
|
|
主題 |
Duodenal polyp |
| 書誌情報 |
en : Techniques and Innovations in Gastrointestinal Endoscopy
巻 24,
号 1,
p. 26-34,
発行日 2021-10-21
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
25900307 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Kumiko Tanakaの学位論文として提出され，学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻） |
| EID |
|
|
識別子 |
383448 |
| 言語 |
|
|
言語 |
eng |
| 報告番号 |
|
|
学位授与番号 |
甲第3588号 |
| 学位記番号 |
|
|
値 |
甲医第1529号 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2022-03-16 |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関名 |
徳島大学 |
k3588_abstract.pdf (121 KB)
