| Item type |
文献 / Documents(1) |
| 公開日 |
2022-05-17 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.69.152 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.69.152 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Bowen disease on the dorsum of the foot associated with human papillomavirus type 16 |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Bowen disease on the foot associated with HPV |
|
言語 |
en |
| 著者 |
村尾, 和俊
山﨑, 佳那子
アガワ, ヒロカズ
ナカジマ, ミヨ
イワサカ, マイコ
久保, 宜明
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A 94 years old Japanese female was presented to our hospital with a skin lesion on her left foot. A physical examination found a markedly hyperkeratotic reddish-brown plaque, measuring 3 cm in diameter. A biopsy specimen showed prominent papillomatosis, hyperkeratosis, and atypical keratinocytes throughout the epidermis. Individual cell keratinization, multinucleated keratinocytes, and many keratinocytes with clear cytoplasm were seen. We excised the lesion, and the skin grafting was used for covering the skin defect. We investigated whether human papillomavirus (HPV) was present in the lesion, and HPV 16 DNA was detected using the polymerase chain reaction. Immunohistochemical analysis showed several HPV-positive cells in the upper epidermis. In addition, the tumor cells showed strong and diffuse expression of p16INK4a. Bowen disease (BD) is an intraepidermal squamous cell carcinoma. The precise pathogenesis of BD is unclear, but it involves various factors. HPV infection is one of these factors and is a well-known cause of BD of the genitalia and fingers. It has been shown that some BD lesions occurring at other locations are also associated with HPV. Dysregulation of the Rb / p16INK4a pathway is considered to play an important role in HPV-induced BD, but the precise mechanism remains to be elucidated. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bowen disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
human papillomavirus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
p16INK4a |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 69,
号 1-2,
p. 152-154,
発行日 2022-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
|
言語 |
en |
| EID |
|
|
識別子 |
388818 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_69_1-2_152.pdf (372 KB)
